126 The selective serotonin reuptake inhibitor fluoxetine exerts anti-inflammatory actions on human epidermal keratinocytes

By releasing several cytokines and mediators (e.g. endothelin 1 [ET1]), keratinocytes are key players in orchestrating cutaneous inflammation and itch. The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FL), a widely applied antidepressant, has already been shown to exert anti-inflammatory actions in mice; thus, in the current study, we assessed putative anti-inflammatory effects of selected SSRIs (FL, citalopram [CP] and paroxetine [PX]) as well as serotonin (ST) on immortalized (HaCaT) and primary (NHEK) human epidermal keratinocytes.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Function Source Type: research