363 The differential production of IL-26 vs. IL-17 by Th17 cells contributes to the development of different forms of psoriasis

Interleukin 17-producing helper T cells (T(H)17 cells) play a role in protection against infections and have also been linked to autoimmune diseases like psoriasis. Th17 cells produce IL-17A/F, IL-22, and IL-26. Whereas the induction of IL-17 and IL-22 expression during Th17 differentiation has been well described, the mechanism regulating the production of IL-26 remains ill defined. Here, we found that IL-6 alone is required to generate IL-26-producing T cells from na ïve T cells but is not sufficient to induce IL-17 producing T cells.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Inflammation, Immunity and Infection Source Type: research