469 Xenobiotic metabolism is triggered in atopic dermatitis

Pollution is known to exacerbate asthma and atopic dermatitis (AD). Moreover, mice overexpressing xenobiotic receptors such as Aryl hydrocarbon receptor (AHR) or pregnane x receptor (PXR), in the epidermis develop AD-like symptoms. Furthermore, we have found increased expression of genes involved in xenobiotic metabolism in the skin of patients with AD but not with ichthyosis vulgaris (IV) by using RNA sequencing technology. To further investigate the possible link between enhanced metabolism of noxious molecules in AD and to validate data from our RNA sequencing analysis, we performed immunohistochemistry and real-time PCR on skin biopsies from AD patients with wild type or mutated fillaggrin or from patients with IV or from healthy controls.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Inflammation, Immunity and Infection Source Type: research