Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins [Signal Transduction]

In conclusion, our results reveal the molecular mechanism underpinning activation of pertussis-like toxins, and we also identified differences in host target specificity.

Source: Journal of Biological Chemistry - September 8, 2017 Category: Chemistry Authors: Dene R. Littler, Sheng Y. Ang, Danilo G. Moriel, Martina Kocan, Oded Kleifeld, Matthew D. Johnson, Mai T. Tran, Adrienne W. Paton, James C. Paton, Roger J. Summers, Mark A. Schembri, Jamie Rossjohn, Travis Beddoe Tags: Editors ' Picks Source Type: research