Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins Signal Transduction

In conclusion, our results reveal the molecular mechanism underpinning activation of pertussis-like toxins, and we also identified differences in host target specificity.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research

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Contributors : Subhash C Verma ; Sankar Adhya ; Soumya G Remesh ; Michal HammelSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliNucleoid remodeling facilitated by DNA supercoiling results in changes in nucleoid configuration and involves nucleoid-associated proteins (NAPs) and structural maintenance of chromosomes (SMC) proteins among others. Changes in nucleoid configurations regulated by NAPs are synchronized with cellular adaptation and influence the simultaneous expression of several genes. HU, a ubiquitous bacterial histone-like protein, is among the most conserved and abunda...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Escherichia coli Source Type: research
We report the synthesis and expression measurement of ~9000 inducible promoter variants. By tagging individual variants with barcodes, we can measure the expression levels of all variants under both induced and uninduced conditions in a single pooled experiment. Sequencing data here is used for 1) paired-end sequencing to map barcodes to their promoters or 2) Quantifying the counts of barcodes at the DNA and RNA levels
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Escherichia coli Source Type: research
Contributors : Pabitra Nandy ; Savita Chib ; Aswin S SeshasayeeSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliRNA Sequencing of wild type Eschrichia coli and a RNA polymerase mutant isolated from deep stationary phase
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Escherichia coli Source Type: research
Contributors : Fernando H Martins ; Ashwani Kumar ; Chao Xing ; Vanessa Sperandio ; Waldir P EliasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAtypical enteropathogenic Escherichia coli (aEPEC) is amongst the leading causes of diarrheal disease worldwide. The colonization of the gut mucosa by aEPEC results in actin pedestal formation at the site of bacterial attachment. This cytoskeletal rearrangement is triggered by the interaction between the bacterial adhesin intimin and its receptor Tir, which is translocated through the type three secretion system, to the host cell. While some...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
I have seen that a few companies are offering paid leave if their workers test positive for COVID19. In theory this is great. In reality, this is bogus.  Policies are worded very specifically. Most of the statements I have seen that list paid leave are for patients that TEST positive for COVID19. The problem is we do not have enough tests! At my practice (a large, tertiary, University-based clinic in Southern California), we are operating under the assumption that most people who contract COVID19 will have a mild form of the disease that will not require a hospital admission. However, they will need...
Source: JeffreyMD.com - Category: Internal Medicine Authors: Tags: After Residency My Life covid19 doctor internal medicine paid leave physician Source Type: blogs
A PaO2/FiO2 ratio (PFR) above 300 is a primary donor criterion for lung transplantation. Absence of cough and respiratory drive in the brain-dead (BD) donor results in basilar atelectasis, contributing to V/Q mismatching and hypoxemia. We hypothesized that ventilating BD donors in the prone position would result in better V/Q matching, increased PFR, and more lungs transplanted.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (941) Source Type: research
Coronavirus is a deadly infection that's easily spread among people, and has now killed more than 1,600 patients in the UK. One man has explained the very first symptom of COVID-19, as well as other signs of the virus you should be looking out for, including a dry cough and a high fever.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
As the COVID-19 pandemic continues to affect the country, most everyone has had to adapt in some way to accommodate this strange new normal—audiologists and hearing researchers included. With calls and procedures for self-quarantine and guidance for small businesses and universities varying from state to state, hearing care professionals may find themselves thrust into new situations. Some are being asked to adopt telepractice for the foreseeable future, and others are quickly switching to virtual-only learning for their audiology students. ASHA is constantly monitoring the situation as it evolves daily. For more inf...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Academia & Research Audiology Health Care News Private Practice Slider audiologist COVID-19 Telepractice Source Type: blogs
Publication date: Available online 30 March 2020Source: Microbial PathogenesisAuthor(s): Jennifer Anne Pienaar, Atheesha Singh, Tobias George Barnard
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Coronavirus is a deadly infection that's killed more than 1,600 people in the UK - and it's continuing to spread. Common signs and symptoms of COVID-19 include a new cough and a high fever, but you could also be at risk of coronavirus if you develop this strange feeling in your nose.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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