UCLA receives $8.4 million NIH grant to help liver transplant recipients stay healthier

(University of California - Los Angeles Health Sciences) UCLA has received an $8.4 million grant from the National Institutes of Health to research ways to help donated livers last longer and improve outcomes for transplant recipients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Backgrounds: Regarding the difficulty of CHC diagnosis and potential adverse outcomes or misuse of clinical therapies, an increasing number of patients have undergone liver transplantation, transcatheter arterial chemoembolization (TACE) or other treatments.Objective: To construct a convenient and reliable risk prediction model for identifying high-risk individuals with combined hepatocellular-cholangiocarcinoma (CHC).Methods: 3369 patients who underwent surgical resection for liver cancer at Zhongshan Hospital were enrolled in this study. The epidemiological and clinical characteristics of the patients were collected at t...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Treatment of advanced heart failure with implantable LVADs is increasing, driven by profound unmet patient need despite potential serious complications: bleeding, infection, and thrombus. The experimental objective was to develop a sensitive imaging approach to assess early thrombus accumulation in LVADs under operational high flow and high shear rates.Methods: A monomeric bifunctional ligand with a fibrin-specific peptide, a short spacer, and 99mTc chelating amino acid sequence (F1A) was developed and compared to its tetrameric PEG analogue (F4A).Results: 99mTc attenuation by LVAD titanium (1 mm) was 23%. 99mTc-F1A affini...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Background and Aims: Down-regulation of GPx3 accelerated hepatic senescence, which further caused overwhelming inflammation and severe liver graft injury. MSCs derived from human induced pluripotent stem cells (hiPSC-MSCs) have been developed as more efficient delivery vehicle with the property of injury tropism. Here, we aimed to explore the suppressive role of GPx3 in hepatic IR injury using novel delivery system of hiPSC-MSCs.Methods: The mice IR injury model with partial hepatectomy was established. The engineered hiPSC-MSCs delivering GPx3 was constructed. All the mice were segregated into three groups. hiPSC-MSC-GPx3...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
PMID: 29912051 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
We report a case of vanishing gastroschisis visualized by antenatal ultrasound with a 7-year long term follow-up. Currently, the child is still dependent on daily parenteral nutrition with no signs of hepatotoxicity. To our knowledge, it ’s the fourth case with a long-term follow-up. Vanishing gastroschisis is a rare complication of gastroschisis. However, physicians should be aware of it because its prognosis is worse than classical gastroschisis. When a vanishing gastroschisis is visualized or suspected by antenatal ultrasound, prenatal counseling is required with explanations about the risk of short bowel syndrome...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research
Transplant Infectious Disease, EarlyView.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Source Type: research
Clinical Transplantation, EarlyView.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Source Type: research
Clinical Transplantation, EarlyView.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Source Type: research
Steven Featley, 23, from Stoke Ash in Suffolk, had his sixth liver transplant last year as part of a lifelong battle with rare condition biliary atresia, which he has had since he was six weeks old.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Steven Featley, 23, from Stoke Ash in Suffolk, had his sixth liver transplant last year as part of a lifelong battle with rare condition biliary atresia, which he has had since he was six weeks old.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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