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UCLA receives $8.4 million NIH grant to help liver transplant recipients stay healthier

(University of California - Los Angeles Health Sciences) UCLA has received an $8.4 million grant from the National Institutes of Health to research ways to help donated livers last longer and improve outcomes for transplant recipients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Matsuda K, Toyama K, Toya T, Ikemura M, Nakamura F, Kurokawa M Abstract A 16-year-old boy with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (HLH) underwent allogeneic hematopoietic stem cell transplantation after conditioning with fludarabine, melphalan, total body irradiation, and rabbit antithymocyte globulin (ATG). A severe, persistent infusion reaction occurred after the initial administration of ATG. Investigations showed a rapid increase in the levels of liver enzymes and ferritin, and the reactivation of HLH was confirmed by marked hemophagocytosis in the bone marrow. Treatment w...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionsSurvival of patients with early post‐transplant sepsis was poor and the incidence of sepsis was associated with the pre‐transplant serum PCT level. Re‐evaluation of the general condition and rescheduling of LT are considered in a patient with pre‐transplant serum PCT>0.5 ng/ml.
Source: Hepatology Research - Category: Internal Medicine Authors: Tags: Original Article Source Type: research
CONCLUSIONS Our results revealed the miRNA signature of DBCD liver grafts for the first time. The miR-146b-5p may have important clinical implications for monitoring liver graft function and predicating transplant outcomes. PMID: 29227984 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - Category: Hematology Source Type: research
This article reviews the research progress for gut microbial a lterations and liver transplantation. Especially, this work also evaluates research on the management of gut microbial alteration and the prediction of possible injuries utilizing microbial alteration during liver transplantation. In addition, we propose possible directions for research on gut micro bial alteration during liver transplantation and offer a hypothesis on the utilization of microbial alteration in liver transplantation. The aim is not only to predict perioperative injuries but also to function as a method of treatment or even inhibit the rejection...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
Researchers at Yokohama City University and Cincinnati Children’s Center for Stem Cell and Organoid Medicine have developed a large-scale method to produce bioengineered liver tissue from human induced pluripotent stem cells (iPSCs). The technique could provide viable, consistently produced liver transplants, offering hope to patients with liver disease. One of the limitations faced by scientists trying to grow certain human cells in the lab for therapeutic purposes is the need to include animal cells in the same environment to help the human cells grow. Such animal cells produce substances that could cause negative...
Source: Medgadget - Category: Medical Devices Authors: Tags: Genetics Materials Surgery Source Type: blogs
Two years after the diagnosis of cirrhotic-stage primary sclerosing cholangitis, a 41-year-old man underwent successful liver transplantation. Three months later he experienced progressive shortness of breath, chest pain, and episodes of exertional syncope. Of note, during the 2-year pretransplant period, the patient had no cardiac complaints, and an echocardiogram performed a few months before the liver transplantation was normal.Figure 1 demonstrates 2 electrocardiograms (ECGs) of the patient.Figure 1A was obtained before the liver transplantation, andFigure 1B was recorded 3 months after the liver transplantation, on de...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Fibrodysplasia Ossificans Progressiva (FOP) is an ultrarare genetic disorder of progressive, disabling heterotopic ossification for which there is presently no definitive treatment. Several recent studies in genetic mouse models of FOP support involvement of the mechanistic target of rapamycin complex 1 (mTORC1) pathway in the pathophysiology of FOP and propose the repurposed use of rapamycin, an inhibitor of mTORC1 signaling in clinical trials for the management of FOP. Here we report two patients with the classic FOP mutation who received rapamycin —one for four months on a compassionate basis for treatment of acut...
Source: Bone - Category: Orthopaedics Authors: Tags: Review Article Source Type: research
We describe the case of a 42-year-old woman with tuberous sclerosis and recent renal transplantation who was critically ill due to pneumonia and had elevation of liver enzymes. She was found to have green refractile inclusions on peripheral blood smear on the third day of hospitalization. The patient improved rapidly with treatment and was discharged in 5  days. It appears that prognostic value of these inclusion bodies is doubtful. We also highlight the need to conduct further studies to clarify the link between hepatic injury and the presence of these inclusions.
Source: Journal of Hematopathology - Category: Pathology Source Type: research
Authors: Gholson CF, McDonald J, McMillan R Abstract Preview How many months of documented abstinence are required before a patient with alcoholic cirrhosis can be considered for liver transplantation? What is the role of liver transplantation as treatment for primary hepatocellular cancer? What are the possible causes of elevated liver enzyme levels following transplantation? Which patients with neurologic injury are potential organ donors? The authors answer these and other questions primary care physicians may have about this lifesaving procedure. PMID: 29219713 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
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