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UCLA receives $8.4 million NIH grant to help liver transplant recipients stay healthier

(University of California - Los Angeles Health Sciences) UCLA has received an $8.4 million grant from the National Institutes of Health to research ways to help donated livers last longer and improve outcomes for transplant recipients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusion: This case may illustrate a resemblance in the renal glomerulus basement membrane and retinal pigment epithelium–Bruch membrane complex, because the authors observed deposits of excess monoclonal kappa chains manifesting as extracellular, proteinaceous aggregates on the basement membrane of the glomerulus, and striking, globular subretinal deposits that overlay a thickened retinal pigment epithelium–Bruch membrane complex. The ocular lesions' refractoriness to intravitreal treatments could be attributed to the fact that they represent proteinaceous aggregates similar to those documented in the glomer...
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
Systemic organ condition should be considered before implantation of left ventricular assist device (LVAD) as a bridge to cardiac transplantation. It is, nevertheless, difficult to evaluate the reversibility of organ function such as kidney and liver which are directly affected by hemodynamics. We experienced a 44-year old woman with autosomal dominant polycystic kidney disease who was also diagnosed with dilated cardiomyopathy. She also had moderately impaired renal function (serum creatinine level: 1.8  mg/dL).
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
ConclusionsTaken together, our observations indicate that regorafenib is beneficial in the treatment of patients with advanced HCC who progressed on or demonstrated intolerance to sorafenib therapy; however, careful selection and close monitoring of patients is necessary to maximize the benefit while minimizing the toxicities of regorafenib treatment.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Opinion statementThe era of hepatitis C virus (HCV) treatment with direct-acting antiviral (DAA) therapy has remarkably improved liver-related morbidity and overall mortality with patients achieving rapid and sustained clearance of HCV infection. The initial DAA clinical trials excluded patients with hepatitis B virus (HBV) co-infection, and thus potential complications were unforeseen until case reports of HBV reactivation associated with DAA therapy began to emerge. A recent United States Food and Drug Administration (FDA) drug safety communication has brought public attention to the issue of HBV reactivation in patients...
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research
We report the case o...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Abstract Controlled oxygenated rewarming (COR) up to 20°C during ex vivo machine perfusion limits reperfusion‐induced tissue injury upon graft implantation. Rewarming up to normothermia might add further benefits and provide better prediction of post‐transplantation organ function. The effect of 90 minutes of oxygenated machine perfusion with Aqix RS‐I after cold storage combined with gentle rewarming up to 20°C (COR20) or 35°C (COR35) was studied in rat livers and compared with cold storage alone (CS, n = 6, resp). Postpreservation recovery was evaluated upon warm reperfusion using an esta...
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
ABSTRACT The positive impact of delayed kidney transplantation (KT) on patient survival for combined liver‐KT (CLKT) has already been demonstrated by our group. The purpose of this study is to identify whether the quality of the kidneys (based on KDPI) or the delayed approach KT contributes to improved patient survival. 130 CLKT were performed between 2002‐2015; 69 with simultaneous KT (Group S) and 61 with delayed KT (Group D) (performed as a second operation with a mean cold ischemia time [CIT] of 50±15h). All patients were categorized according to the KDPI score; 1‐33%, 34‐66%, and 67‐99%. Recipient and...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Conclusion: The varied surgical approaches in the A2ALL centers offer a novel opportunity to compare disparate LDLT approaches. The choice to use higher biliary radicals on the recipient duct for reconstruction was associated with more BC, possibly secondary to devascularization and ischemia. The use of Roux‐en‐Y biliary reconstruction was associated with vascular complications (HAT and PVT). These results can be used to guide biliary reconstruction decisions in the setting of anatomic variants and inform further improvements in LDLT reconstructions. Ultimately, this information may contribute to a lower incidence of t...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Publication date: Available online 18 September 2017 Source:Molecular Genetics and Metabolism Author(s): Ayman W. El-Hattab, Ana Maria Zarante, Mohammed Almannai, Fernando Scaglia Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular defects in genes encoding mitochondrial proteins. Despite the advances in molecular and biochemical methodologies leading to better understanding of the etiology and mechanism of these diseases, there are still no satisfactory therapies available for mitochondrial di...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
We read with interest the study by Nadim et al[1] identifying inequality in organ allocation for patient awaiting liver transplant (LT) in the United States (U.S.). In depth, the Model for End-stage Liver Disease (MELD) score is artificially capped at 40 and thus actually disadvantages the sickest patients with end-stage liver diseases. In Nadim et al.[1] study, Figure 1 presents exponential increased the number of transplanted patients with MELD ≥ 40. As response to the increased demand of this population since year 2002, the “Share 35” that prioritized patients with MELD ≥ 35 within the donor’s Or...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
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