Statins May Help People With COPD Live Longer

Deaths from lung - related causes were reduced by as much as 45 percent, study suggests
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Pharmacy, Pulmonology, News, Source Type: news

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CONCLUSIONS: These results demonstrate exposure-response relationships between indoor BC with biomarkers of systemic inflammation in COPD patients, with stronger relationships in persons not using statins and with diabetes. PMID: 29783085 [PubMed - as supplied by publisher]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
In conclusion, the modulation of histone acetyltransferase/deacetylase activity may lead to the development of novel anti-inflammatory approaches to inflammatory lung diseases that are currently difficult to treat. PMID: 29782855 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
CONCLUSIONS: Observational studies are important to provide evidence from real-world data on medication effects. However, appropriate study design and analysis are essential to avoid biases and ensure randomized trials with greater chances of success. The observational studies suggesting potential beneficial effects of non-respiratory drugs to treat COPD, such as statins and beta-blockers, will also need careful review before embarking on long and expensive randomized trials. PMID: 29679596 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
ConclusionsOur model indicates that the current NHS Health Check programme is contributing to improvements in health and reducing health inequalities. Feasible changes in the organisation of the programme could result in more than a 3-fold increase in health benefits.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionsMultimorbidity among patients with AMI was common, and conferred an accumulative increased risk of death. Three multimorbidity phenotype clusters that were significantly associated with loss in life expectancy were identified and should be a concomitant treatment target to improve cardiovascular outcomes. Trial NCT03037255.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
AbstractAimof this study is to determine the temporal resolution of therapy-induced pneumonitis, and to assess promoting factors in adjuvant treated patients with unilateral mammacarcinoma.Patients and methodsA  total of 100 post-surgery patients were recruited. The cohort was treated by 2 field radiotherapy (2FRT; breast and chest wall,N = 75), 3 field radiotherapy (3FRT; + supraclavicular lymphatic region,N = 8), or with 4 field radiotherapy (4FRT; + parasternal lymphatic region,N = 17). Ninety-one patients received various systemic treatments prior to irradiation. Foll...
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
PMID: 29406229 [PubMed - in process]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Abstract Asthma and chronic obstructive pulmonary disease (COPD) are the two most prevalent obstructive lung diseases that account for tremendous morbidity and mortality throughout the world. These diseases have strong inflammatory components, with multiple prior studies showing elevated levels of various inflammatory markers and cells in those with COPD and asthma. Therefore, efforts to target inflammation in management of these diseases are of great interest. Statins, which define a class of drugs that are HMG-CoA inhibitors, are used to decrease cholesterol levels and have also been described to have many pleot...
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Opin Pharmacol Source Type: research
(MedPage Today) -- Meta-analysis sheds light on statin use in COPD
Source: MedPage Today Pulmonary - Category: Respiratory Medicine Source Type: news
Conclusion: Individuals with COPD have higher risk of developing PAD. This emphasizes the importance of determining ABI for the diagnosis of PAD in the management of patients with COPD.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
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