Fully Funded PhD position: Pattern Recognition Receptors in Antimicrobial Immunity
This study explores the possible application of biogenic silver nanoparticles produced from gum kondagogu as potent antifungal agents. The potent antifungal activity of Gk-AgNPs gives scope for its relevance in biomedical application and as a seed dressing material.
Conclusions UV-C disinfection system was effective in killing MDR pathogens. Further study is warranted to confirm its effectiveness as an adjunctive method in disinfecting hospital environment.
Publication date: Available online 18 September 2017 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): M. Sankarganesh, P. Adwin Jose, J. Dhaveethu Raja, M.P. Kesavan, M. Vadivel, J. Rajesh, R. Jeyamurugan, R. Senthil Kumar, S. Karthikeyan In this research work, we have synthesized new pyrimidine based Schiff base ligand, 2-((4,6-dimethoxypyrimidine-2-yl)methyleneenamino)-6-methoxyphenol (DPMM) capped gold (Au) and platinum (Pt) nanoparticles (NPs) by modified Brust-Schiffrin method. The characteristics of DPMM-Au NPs and DPMM-Pt NPs have been examined by UV–Visible, FTIR, SEM, TEM and powder X...
Mon, 09/18/2017 - 15:12News blog
Conclusions: A precise and highly sensitive liquid chromatography-tandem mass spectrometry method was developed that enables quantification of triazoles in plasma and serum matrix across therapeutically relevant concentration ranges. It was successfully implemented in our therapeutic drug monitoring routine service and is suitable for routine monitoring of antifungal therapy and in severely ill patients.
er O Abstract The incidence of azole resistance in Aspergillus species has increased over the past years, most importantly for Aspergillus fumigatus. This is partially attributable to the global spread of only a few resistance alleles through the environment. Secondary resistance is a significant clinical concern, as invasive aspergillosis with drug-susceptible strains is already difficult to treat, and exclusion of azole-based antifungals from prophylaxis or first-line treatment of invasive aspergillosis in high-risk patients would dramatically limit drug choices, thus increasing mortality rates for immunocomprom...
In this study, high-throughput RNA-seq was used to investigate salt stress-induced genes in the parent, ΔcnaB, and ΔcnaBΔcchA strains of Aspergillus nidulans, which differ greatly in salt adaption. In total, 2,884 differentially expressed genes including 1,382 up- and 1,502 downregulated genes were identified. Secondary transporters, which were upregulated to a greater extent in ΔcnaBΔcchA than in the parent or ΔcnaB strains, are likely to play important roles in response to salt stress. Furthermore, 36 genes were exclusively upregulated in the ΔcnaBΔcchA under salt stress. F...
Zuzana Hruska, Haibo Yao, Russell Kincaid, Robert L. Brown, Deepak Bhatnagar, Thomas E. Cleveland