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Acromegaly and bone.

CONCLUSIONS: In this article, we summarize the pathophysiology, clinical aspects and the new diagnostic tools to better understand bone impairment in acromegaly. PMID: 28880058 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

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The 'trendy' diet of intermittent fasting may have adverse consequences on our metabolism, a new study warns. The diet may impair pancreatic function.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Diabetes Type 2 Source Type: news
New study also suggests regimes that include intermittent fasting may cause other long-term health problemsFasting every other day to lose weight could have damaging side effects. That is the conclusion of a group of scientists speaking this weekend at the European Society of Endocrinology ’s annual meeting.Their findings suggest that fasting-based diets may impair the action of sugar-regulating hormone insulin, and lead to increased risk of diabetes. Care should be taken before starting such programmes, say researchers.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Diabetes Medical research Diets and dieting Life and style Society UK news Science Source Type: news
CONCLUSIONS: Our study showed that β-blockers during the ICU stay had no significant association with mortality or morbidity. However, β-blocker therapy was associated with increased mortality in non-diabetic patients. TRIAL REGISTRATION: ISRCTN07413772 ; (dated 13.07.2005). PMID: 29769112 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
In this study, a sensitive and efficient UPLC-MS/MS method for the quantification of canagliflozin and its metabolites in rat plasma was established and applied to pharmacokinetics in a type 2 diabetic rat model. We firstly investigated the pharmacokinetic changes of canagliflozin and its metabolites in type 2 diabetic rats in order to use canagliflozin more safely, reasonably and effectively. We identified three types of O-glucuronide metabolites (M5, M7 and M17), two kinds of oxidation metabolites (M8 and M9) and one oxidation and glucuronide metabolite (M16) using API 5600 triple-TOF-MS/MS. Following liquid–li...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 19 May 2018 Source:Trends in Endocrinology & Metabolism Author(s): Jacqueline M. Ratter, Cees J. Tack, Mihai G. Netea, Rinke Stienstra The environment induces metabolic reprogramming of immune cells via specific signaling pathways. Recent studies have revealed that changes in cell metabolism affect key immune cell functions including cytokine production and migration. In diabetes, these functions are either insufficiently or excessively activated, translating into diabetes-associated complications, including increased susceptibility to infection and accelerated cardiovascular disease...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
ConclusionsSG seems effective and safe in obese HIV patients. However, ART treatment should be monitored post-SG to control HIV infection. We suggest that some ART should be adapted  before SG conjoints with infectious disease specialists.
Source: Obesity Surgery - Category: Surgery Source Type: research
Conclusions: The DSM app was developed based on behavioral change theory through IMB models. It was designed to be evidence-based, user-centered, and effective. It remains necessary to fully evaluate the effect of the DSM app on the DSM behavior changes of diabetes patients. PMID: 29770246 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
Authors: Sirtori CR, Pavanello C, Calabresi L, Ruscica M Abstract Metabolic Syndrome (MetS), affecting at least 30% of adults in the Western World, is characterized by three out of five variables, from high triglycerides, to elevated waist circumference and blood pressure. MetS is not characterized by elevated cholesterolemia, but is rather the consequence of a complex interaction of factors generally leading to increased insulin resistance. Drug treatments are of difficult handling, whereas well-characterized nutraceuticals may offer an effective alternative. Among these, functional foods, e.g. plant proteins, hav...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Authors: Iciek R, Brazert M, Wender-Ozegowska E, Pietryga M, Brazert J Abstract Type 1 diabetes mellitus (T1DM) is still related to altered fetal growth and severe maternal complications. We studied the possible role of placental visfatin/nicotinamide phosphoribosyltransferase (NAMPT) in fetal development in T1DM pregnancies, the possible role of placental visfatin in fetal macrosomia. Sixty five pregnant women with T1DM and singleton pregnancy were qualified into the study. Placental visfatin expression was by analysed by RT-PCR. We demonstrated the lowest expression of placental visfatin in women who delivered ne...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Study of anti-Müllerian hormone levels in patients with Myotonic Dystrophy Type 1. Preliminary results. Acta Myol. 2017 Dec;36(4):199-202 Authors: Ergoli M, Venditti M, Dotolo R, Picillo E, Minucci S, Politano L Abstract Myotonic dystrophy type 1 is a multisystemic disorder characterized by myotonia, muscle weakness and involvement of several organs and apparatus such as heart, lungs, eye, brain and endocrine system. Hypogonadism and reproductive abnormalities are frequently reported. A progressive testicular atrophy occurs in about 80% in the affected males leading to Leydig cell hyperproliferati...
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
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