Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2 —Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues

Veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is a potentially fatal complication associated with hematopoietic stem cell transplatation (HCT) [1-4]. The reported heterogeneity in the management of children with VOD is likely related to the dearth of published evidence [5-11]. Conducting appropriately powered randomized controlled trials in the pediatric cohort is logistically challenging; thus, extrapolation from indirect evidence is often the best means of guiding management.

Source: Biology of Blood and Marrow Transplantation - August 17, 2017 Category: Hematology Authors: Kris M. Mahadeo, Jennifer McArthur, Roberta H. Adams, Mohamed Radhi, Joseph Angelo, Asumthia Jeyapalan, Kathleen Nicol, Leon Su, Hanna Rabi, Jeffery J. Auletta, Vinita Pai, Christine N. Duncan, Robert Tamburro, Christopher C. Dvorak, Rajinder P.S. Bajwa Source Type: research