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Macrodystrophia Lipomatosa

We present a 25‐year‐old man who presented with overgrowth of the right hand associated with occasional pain, numbness, and limited function who was found to have macrodystrophia lipomatosa with fibrolipomatous hamartoma of the median nerve. Reports of this condition are limited in the dermatology literature, and early recognition can lead to better outcomes.
Source: Pediatric Dermatology - Category: Dermatology Authors: Tags: Brief Report Source Type: research

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Abstract Orofacial changes are frequent in acromegaly. Their evolution is slowly progressive. The lips (everted and thickened), the mandibular morphology (prognathism), the tongue (macroglossia), the soft palate and the uvula (increased and thickened), the parodontis (gingival hyperplasia, paradontitis), the teeth (increased interdental spaces, hypercementosis, increased dental mobility, multiple tooth loss) are concerned. Functional consequences are significant (obstructive sleep apnea syndrome, malocclusion, pain of the oral maxillofacial area, decrease of the quality of life). They are rarely noticed as the fir...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
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Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Case Report Source Type: research
(MedPage Today) -- Case Findings: A 42-year-old male presents with a long history of headaches, impaired vision, and fatigue. He mentions that his wedding ring no longer fits, and he reports joint pain. On physical exam, he has swollen hands and feet, coarse facial features, and partial blindness (bitemporal hemianopsia). After diagnosis with acromegaly secondary to a pituitary macroadenoma, the patient is referred for surgery. However, the patient's IGF-1 concentrations remain elevated following a debulking procedure (the tumor location prevented full resection). What is the best next step for this patient?
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news
DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 167 Question 1 What is Asturian leprosy? + Reveal the Funtabulous Answer expand(document.getElementById('ddet358938163'));expand(document.getElementById('ddetlink358938163')) Pellagra or vitamin B3 (niacin) deficiency as a result of a corn based diet (Noted in the Asturias community in Spain). In 1915, back when such practices were legal and under the Surgeon General’s sanction in the USA, Dr. Goldbe...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five acromegaly Andre the giant as you wish Asturian leprosy bicyclists vulva brown sequard Jake leg OPIDN organophosphate induced delayed neuropathy Pellagra placebo vitamin B3 Source Type: blogs
At 7 feet 8 inches, Broc Brown definitely sticks out in a crowd, and he’s only going to get bigger. Brown’s family knew something was up at a young age: He was 5-foot-2 in kindergarten, according to his mother, Darci Elliot. “When he got into middle school he was around 6 feet tall, and by high school he was 7 feet tall,” Elliot told Barcroft TV. “It’s a genetic disorder and there’s nothing that can stop him from growing – I don’t know if he will ever stop.” Brown, 19, grows an astounding six inches a year because of a rare genetic disorder called S...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Discussion Constipation is a common problem in general pediatrics and its causes are numerous. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. This patient had undergone some evaluations in the past for constipation but because of the presentation of sepsis a more rigorous evaluation was undertaken. The differential diagnoses of the following can be found here: constipation, acute abdominal pain, recurrent abdominal pain, and abdo...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Most people view their twice-yearly visits to the dentist as little more than a cleaning and a check-up. But in reality, those visits are much more important than you probably realize. That's because your dentist is looking inside your mouth for a lot more than cavities. Plenty of medical conditions -- including some alarming ones! -- manifest in the mouth, which is the part of your body your dentist knows the most about. In fact, it's possible that your dentist is able to alert you of a potentially serious condition long before you even think about going to a primary care doctor. Here's a list of some of the medical cond...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Authors: Grasso LF, Auriemma RS, Pivonello R, Colao A Abstract INTRODUCTION: In patients with acromegaly, somatostatin analogs (SSA) represent the first choice medical treatment. The long-acting SSA have been found to be effective in controlling growth hormone and IGF-I levels in a high percentage of patients, resulting in an improvement in the quality of life; moreover, these peptide analogs have a proven safety record and are generally well tolerated. AREAS COVERED: The most commonly reported adverse events include injection-site discomfort and erythema, gastrointestinal (GI) disturbances such as diarrhea, ab...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia…introducing Funtabulously Frivolous Friday Five 120 Question 1 What rheumatological condition does Rembrandt’s Scholar have? + Reveal the Funtabulous Answer expand(document.getElementById('ddet1210722826'));expand(document.getElementById('ddetlink1210722826')) Scleroderma He has a pinched nose, tight mouth, pale face with a malar flush, his hands are puffy and the joints on his right thumbs are swollen. Could this be Scleroderma? [Reference] Question 2 When Ra...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five collapse dentist FFFF hands Kluver-bucy syndrome melanoma pleural collapse rachmaninoff rachmaninov Rembrandt scleroderma TB teeth temporal lobe Source Type: blogs
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