Alterations in hematologic indices during long-duration spaceflight

ConclusionsWhile susceptible to the possible influence of dehydration or plasma volume alterations, these results suggest astronauts do not develop persistent anemia during spaceflight.
Source: BMC Hematology - Category: Hematology Source Type: research

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Authors: Sayad A, Dehaghi MO, Taheri M, Fallah H, Arsang-Jang S, Shadnoush M, Ghafouri-Fard S, Hamidieh AA Abstract Fanconi anemia includes a number of clinically and genetically diverse disorders all of them being associated with genomic instability. Some previous studies reported higher frequencies of certain HLA alleles in patients with Fanconi anemia. In the current study, we genotyped HLA-A/B/DRB1 alleles in 40 Iranian patients with Fanconi anemia. We also genotyped these alleles in the same number of Iranian sex-matched healthy individuals. The frequency of DRB1*11 was significantly higher in patients compare...
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
Purpose of review We will examine the current and future options in management of anemia in dialysis patients focusing on recent trials in iron supplementation and alternatives to erythropoietin-stimulating agents (ESAs). Recent findings We review the literature on Erythropoietin (EPO)-stimulating agents, focusing on the risk benefits of various options available. We review the recent practice changing trial in iron supplementation in dialysis patients with chronic kidney disease and movements in the research on alternatives to EPO-stimulating agents primarily hypoxia-inducible factor prolyl hydroxylase inhibitors (HI...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: EPIDEMIOLOGY AND PREVENTION: Edited by Navdeep Tangri Source Type: research
Conclusions: IDA significantly increases autoimmune disease risk, particularly in female patients and patients with certain comorbidities. Clinicians should conduct further clinical evaluations and laboratory tests of autoimmune disease in patients with IDA.Plain Language Summary: Little is known about the relationship between iron deficiency and autoimmune disease. By using a national-level database in Taiwan, we noted a meaningful association between iron deficiency anemia (IDA) and later autoimmune disease development. Our study extends the known disease range and recommends that physicians be alert for the occurrence o...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Background. Frailty is a clinically recognized syndrome of decreased physiological reserve and a key contributor to suboptimal clinical outcomes in various lung disease groups. Interstitial lung disease (ILD) is fast approaching chronic obstructive pulmonary disease as the number one indication for lung transplantation worldwide. Our aim was to assess whether frailty is a predictor of mortality in patients with ILD referred for lung transplantation in an Australian cohort. Methods. Consecutive patients with ILD referred or on the waiting list for lung transplantation from May 2013 to December 2017 underwent frailty as...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Dyspnea is one of the commonest complaints encountered in practice. Etiologies span the gamut of internal medicine and range from anemia to deconditioning to pulmonary and cardiac disorders. In the latter category, heart failure (HF) is one of the more common and serious causes of dyspnea and also one of the most challenging to diagnose.1 In patients with classical symptoms (orthopnea, paroxysmal nocturnal dyspnea) and unequivocal congestion on physical examination (jugular distention, edema, rales, gallop sounds), the diagnosis is straightforward.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Editorial Source Type: research
Anemia may confer a poor prognosis among patients with acute coronary syndrome. However, contemporary data are lacking on the prognostic importance of anemia in patients with left ventricular (LV) systolic dysfunction after acute myocardial infarction (AMI).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (570) Source Type: research
Mrs. S is an 85-year-old woman who moved into the nursing home five years ago when her husband could no longer provide care for her due to her progressive weakness and failure to thrive. She has a history of Barrett ’s esophagus and significant reflux and subsequent dysphagia, a long history of depression, allergic rhinitis, dementia with a Brief Interview for Mental Status (BIMS) score of 12, basal cell carcinoma, insomnia, iron deficiency anemia, and a pneumonitis due to aspiration. She is oxygen dependent.
Source: Caring for the Ages - Category: Health Management Authors: Tags: Interdisciplinary Team Case Studies Source Type: news
The impact of iron deficiency anemia on hospital length of stay and in hospitalization mortality has not been investigated in patients whose main reason for admission is pulmonary arterial hypertension. We sought to compare the outcomes in hospitalization in patients with pulmonary arterial hypertension (PAH) with a diagnosis of iron deficiency anemia (IDA) versus those without from a large sample database.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1317) Source Type: research
Iron deficiency anemia (IDA) persists after left ventricular assist device (LVAD) placement and is associated with increased hospitalizations and mortality. Correction of IDA with IV iron replacement in patients with heart failure improves quality of life (QoL), functional capacity, and reduces hospitalizations. Minimal data for IV iron replacement in patients with LVAD exists. We sought to assess the safety and efficacy of protocolized iron deficiency diagnosis and IV iron replacement in newly implanted LVAD recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1304) Source Type: research
Condition:   Severe Aplastic Anemia (SAA) Interventions:   Drug: eltrombopag;   Drug: rabbit anti-thymocyte globulin (r-ATG);   Drug: cyclosporine A (CsA) Sponsor:   Novartis Pharmaceuticals Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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