Tissue - engineering as an adjunct to pelvic reconstructive surgery.

CONCLUSION: In two rat abdominal wall models, cells from autologous MFFs, seeded on the quickly degradable MPEG-PLGA scaf-fold, survived implantation and contributed to the regenerative process by forming extra striated muscle fibers and influencing the biomechanical properties of the regenerated tissue. Consequently, MFFs seeded on an MPEG-PLGA scaffold is a potentially advantageous cell-delivering strategy to regenerate tissue at pelvic reconstructive surgery. In three rat abdominal wall models, a long-term degradable PCL scaffold caused a marked foreign-body response and formed a neo-tissue PCL construct that provided biomechanical tissue reinforcement to the abdominal wall, even at maximal load. Consequently, the PCL scaffold might be beneficial in pelvic reconstructive surgery, providing initial biomechanical rein-forcement, although long-term studies showing the tissue response at full degradation are required. Cells from the MFFs did not survive in or around the neo-tissue PCL construct, possibly because of the massive inflammatory response. Consequently, as a scaffold material, with the purpose of delivering cells to a specific anatomical site, the PCL scaffold seems poor. A transabdominal rabbit vaginal model was feasible and might be advantageous in the evaluation of meshes used for pelvic reconstructive surgery, especially when long-term studies are needed. PMID: 28869032 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research