Microbiota, metabolome, and immune alterations in obese mice fed a high ‐fat diet containing type 2 resistant starch

ConclusionConsumption of RS modified the intestinal microbiota, stimulated intestinal immunity and endocrine‐responses, and modified systemic metabolomes in obese mice consuming an otherwise obesogenic diet. Inclusion of type 2 resistant starch (RS) into high‐fat diet of obese mice induced alterations to hormonal and immune responses in the intestinal and adipose tissues. RS feeding also enhanced intestinal fermentation and altered gut microbiota and metabolomes in blood and liver including decreases in amino acids quantities. Glucose and maltose increased in the intestinal contents with RS consumption. Urinary metabolites differed between RS‐fed mice and control mice. These changes are mediated, at least partly, via alterations to the composition and function of gut microbiota.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research