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'Listen to women': UK doctors issued with first guidance on endometriosis

Disease, which causes crippling pain and can lead to infertility, affects 176 million women worldwide and currently takes seven to eight years to diagnoseYears of pain, but no diagnosis: one woman ’s experience of endometriosisDoctors are being advised to listen to what women tell them about crippling pelvic and period pain and look out for the symptoms of endometriosis in a bid to speed up diagnosis of a disease that can wreck lives and careers.It takes an average of seven to eight years to be diagnosed with endometriosis, according to the first-ever guidance on managing a disease that affects one in 10 women from the National Institute for Health and Care Excellence (Nice) in England. Experts say the long wait is the same all over the western world. Many women are told they are making a fuss about normal period pain. Some are unable to work and the disease causes others to become infertile.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Endometriosis Health Society The National Institute for Health and Care Excellence (Nice) NHS Women Sexual health Menstruation Source Type: news

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Conclusion: NR4A1 can regulate fibrosis in endometriosis and may serve as a new target for the treatment of endometriosis.Cell Physiol Biochem 2018;46:1078 –1090
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Authors: Donnez J, García-Solares J, Dolmans MM Abstract Endometriosis is a frequently encountered benign gynecological disease that may be responsible for infertility. Treatment of endometriosis-associated infertility has been investigated using both medical and surgical therapeutic modalities. Therapy has essentially three main objectives: (i) to preserve and improve fertility, (ii) to reduce pain, and (iii) to delay recurrence. The aim of this paper is to focus on fertility preservation in women with severe endometriosis. In ovarian endometriosis-associated infertility, a medico-surgical approach remains ...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
Publication date: Available online 6 April 2018 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Ioannis Simitsidellis, Douglas A. Gibson, Philippa T.K. Saunders Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation o...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research
Endometriosis is one of the most common reproductive disorders affecting women. Characterized by the presence of endometrial tissue outside the uterine cavity, it is a heterogeneous disease that can affect different anatomical sites, mainly the ovaries and the peritoneum. All forms of endometriosis cause varying degrees of pelvic pain, dysmenorrhea, dyspareunia, painful defecation, and/or infertility. Although the estimated prevalence of endometriosis is 6% –10% in the general female population, it affects an estimated 35%–50% of infertile women.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Endometriosis is one of the most common reproductive disorders affecting women. Characterized by the presence of endometrial tissue outside the uterine cavity, it is a heterogeneous disease that can affect different anatomical sites, mainly the ovaries and the peritoneum. All forms of endometriosis cause varying degrees of pelvic pain, dysmenorrhea, dyspareunia, painful defecation, and/or infertility. Although the estimated prevalence of endometriosis is 6% –10% in the general female population, it affects an estimated 35%–50% of infertile women.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Like endometriosis, uterine adenomyosis is another enigmatic disease and remains a source of controversy. Uterine adenomyosis is characterized by the presence of endometrial glands in the myometrium. Two main theories may explain its pathogenesis: adenomyosis may arise from invagination of the myometrial basalis into the myometrium; or an alternative theory maintains that it may result from metaplasia of displaced embryonic pluripotent m üllerian remants or differentiation of adult stem cells. Uterine adenomyosis is responsible for pelvic pain, abnormal bleeding, and infertility.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
Endometriosis is a chronic, estrogen dependent condition that affects 5 –10% of reproductive aged women and is associated with pelvic pain and infertility. As the approach to therapy shifts from surgical ablation to pharmacological control, a non-surgical mode of diagnosis would be desirable. The ENDOmarker study was designed by the NICHD Reproductive Medicine Network (RMN) to obtain well characterized and phenotyped bio specimens in a standardized fashion from women with and without endometriosis.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research
ConclusionOwing to the possibility to perform a complete assessment of all pelvic compartments at one time, MRI represents the best imaging technique for preoperative staging of endometriosis, in order to choose the more appropriate surgical approach and to plan a multidisciplinary team work.Teaching Points• Endometriosis includes ovarian endometriomas, peritoneal implants and deep pelvic endometriosis.• MRI is a second-line imaging technique after US.• Deep pelvic endometriosis is associated with chronic pelvic pain and infertility.• Endometriosis is characterized by considerable diagnostic delay.&bull...
Source: Insights into Imaging - Category: Radiology Source Type: research
Publication date: Available online 14 February 2018 Source:Best Practice & Research Clinical Obstetrics & Gynaecology Author(s): Bansari G. Patel, Emily E. Lenk, Dan I. Lebovic, Yimin Shu, Jie Yu, Robert N. Taylor Despite an estimated prevalence of 11% in women and plausible historical descriptions dating back to the 17th century, the etiology of endometriosis remains poorly understood. Classical theories of the histological origins of endometriosis are reviewed below. Clinical presentations are variable and signs and symptoms do not correlate well with the extent of disease. In this summary we have attempted to s...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
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