'Listen to women': UK doctors issued with first guidance on endometriosis

Disease, which causes crippling pain and can lead to infertility, affects 176 million women worldwide and currently takes seven to eight years to diagnoseYears of pain, but no diagnosis: one woman ’s experience of endometriosisDoctors are being advised to listen to what women tell them about crippling pelvic and period pain and look out for the symptoms of endometriosis in a bid to speed up diagnosis of a disease that can wreck lives and careers.It takes an average of seven to eight years to be diagnosed with endometriosis, according to the first-ever guidance on managing a disease that affects one in 10 women from the National Institute for Health and Care Excellence (Nice) in England. Experts say the long wait is the same all over the western world. Many women are told they are making a fuss about normal period pain. Some are unable to work and the disease causes others to become infertile.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Endometriosis Health Society The National Institute for Health and Care Excellence (Nice) NHS Women Sexual health Menstruation Source Type: news

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Abstract Endometriosis, a common gynecological disease, is associated with pelvic pain and infertility. Endometriosis affects approximately 10% of women, but that number increases to 30-50% in symptomatic premenopausal women. Despite the prevalence of endometriosis, the cause has yet to be fully elucidated. Recent study of the molecular pathways of endometrial cancer has brought the long non-coding RNA (lncRNA) H19 to our attention. In this paper, we explored the role of lncRNA-H19 in endometrial tissue proliferation. We found that ectopic endometrial cells taken from women with endometriosis showed elevated level...
Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research
CONCLUSIONS: The omega-6/3 and omega-9/6 nutraceuticals decreased pain compared to the controls. There was no improvement in fertility in any of the tested groups. PMID: 31066787 [PubMed - in process]
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
(Abstracted from J Minim Invasive Gynecol 2019;26:71–77) The primary sequelae of endometriosis are infertility and chronic pelvic pain (CPP). Nearly 40% of women with endometriosis are infertile, and 71% to 87% have CPP.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: OPERATIVE GYNECOLOGY Source Type: research
Authors: Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J Abstract Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extra-uterine endometriotic tissue involve defectively progr...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
ConclusionsWe have identified menstrual cycle- and endometriosis-associated protein changes linked to various cellular processes that are potential biomarkers and that provide insight into the biology of endometriosis. Our data indicate that the markers tested, whilst not useful alone, have improved diagnostic accuracy when used in combination and demonstrate menstrual cycle specificity. Tissue heterogeneity and blood contamination is likely to have hindered biomarker discovery, whilst a small sample size precludes accurate determination of performance by cycle phase. Independent validation of these biomarker panels in a l...
Source: Clinical Proteomics - Category: Biochemistry Source Type: research
Conclusions and Relevance Cystectomy of ovarian endometriomas has been the first-line treatment for management for many years because it provides improved pain relief, reduces recurrence rates, and was thought to be favorable in in vitro fertilization. However, a growing body of evidence is demonstrating benefit, or at least no harm, in expectant management for asymptomatic patients with small, stable endometriomas. Medical management is often very effective and appropriate first line. When surgical intervention is appropriate, careful ovarian cyst excision with goal of ovarian tissue preservation and treatment of additi...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research
March is Endometriosis Awareness Month.  Endometriosis is a painful condition where endometrial tissue grows outside the uterus. It is estimated that up to 10% of women have endometriosis (Ozkan 2008).   Endometriosis can cause infertility and for women with subfertility the prevalence rate ranges from 25% to 40% (Ozkan 2008). Endometriosis frequently presents with the symptom of pain (Barlow 1993) including dysmenorrhoea (painful periods), dyspareunia (pain during sexual intercourse), and pelvic or abdominal pain.  We invited Edgardo Somigliana, MD-PhD (Dept Clinical Sciences and Community Health, Universit...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Abstract Endometriosis is characterized by extra-uterine growth of endometrial tissue accompanied by adverse clinical manifestations including chronic pelvic pain and infertility. Retrograde menstruation, the efflux of endometrium into the peritoneal cavity during menstruation, is believed to contribute to implantation of endometrial tissue and formation of endometriotic lesions at ectopic sites. While it is established through various rodent and non-human primate models that endometrial tissue fragments, as well as non-dissociated stroma and glands, are capable of seeding endometriosis in a manner mimicking retro...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
We present an interesting case of a nulliparous patient that underwent laparoscopic surgery for pelvic endometriosis and 2 years after a laparoscopic excision of an intraligamentous fibroid.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Movies Technique 1 – Surgical techniques in Gynaecology Source Type: research
Introduction: Endometriosis is an enigmatic disease affecting up to 10% of reproductive-aged women causing pain and infertility. Deep infiltrating endometriosis (DIE) is the most severe form of the disease. The impact of surgical treatment for deep endometriosis on fertility success rate of assisted reproduction techniques (ART) is not clear.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Session 24 – Reproductive Medicine Source Type: research
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