'Listen to women': UK doctors issued with first guidance on endometriosis

Disease, which causes crippling pain and can lead to infertility, affects 176 million women worldwide and currently takes seven to eight years to diagnoseYears of pain, but no diagnosis: one woman ’s experience of endometriosisDoctors are being advised to listen to what women tell them about crippling pelvic and period pain and look out for the symptoms of endometriosis in a bid to speed up diagnosis of a disease that can wreck lives and careers.It takes an average of seven to eight years to be diagnosed with endometriosis, according to the first-ever guidance on managing a disease that affects one in 10 women from the National Institute for Health and Care Excellence (Nice) in England. Experts say the long wait is the same all over the western world. Many women are told they are making a fuss about normal period pain. Some are unable to work and the disease causes others to become infertile.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Endometriosis Health Society The National Institute for Health and Care Excellence (Nice) NHS Women Sexual health Menstruation Source Type: news

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Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis. Mol Med Rep. 2019 Jan 03;: Authors: Albertsen HM, Matalliotaki C, Matalliotakis M, Zervou MI, Matalliotakis I, Spandidos DA, Chettier R, Ward K, Goulielmos GN Abstract Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a major cause of pain and infertility. The familial association of...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ABSTRACT Introduction: Endometriosis is a chronic gynecological condition characterized by the presence of endometrial tissue in locations outside the uterus. Its symptoms include dysmenorrhea, dyspareunia, chronic pelvic pain, infertility, dysuria, and dyschezia. Several studies have related the vascular endothelial growth factor (VEGF) gene polymorphisms as a factor for the development of endometriosis. Objectives: The aim of this study was to compare the frequency of the VEGF gene polymorphism rs35569394 in women with endometriosis and a control group, as well as to investigate the association of this polymorphism with ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus and causes chronic pelvic pain and infertility. However, the exact mechanisms of the pathogenesis of endometriosis-associated infertility are unknown. Epigenetic dysregulation has recently been implicated in infertility. Here, we report a reduction of histone deacetylase 3 (HDAC3) protein amounts in eutopic endometrium of infertile women with endometriosis compared to a control group. To investigate the effect of HDAC3 loss in the uterus, we generated mice with conditional ablation of Hdac3 in progesterone receptor (PG...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Endometriosis can have a profound impact on women ’s lives, including associated pain, infertility, decreased quality of life, and interference with daily life, relationships, and livelihood. The first step in alleviating these adverse sequelae is to diagnose the underlying condition. For many women, the journey to endometriosis diagnosis is long and fraught with barriers and misdiagnoses. Inherent challenges include a gold standard based on an invasive surgical procedure (laparoscopy) and diverse symptomatology, contributing to the well-established delay of 4 to 11 years from first symptom onset to surgical diagnosis.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Call to Action Source Type: research
(CNN) — People were curious about the keto diet, ALS and endometriosis in 2018. Those are just a few of the health-related topics that had Internet surfers in the United States turning to Dr. Google with questions this year, according to a top 10 list from the search engine giant. The data, based on search terms, was collected from January to mid-December. Last year, some of the top health-related questions searched on Google included what causes hiccups, how to stop snoring, how long flu lasts and what is lupus. Some of the top health-related questions on Google in 2016 were related to Zika, traumatic brain injuries...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat Google Local TV Source Type: news
We report a case of a rectovaginal mass found during a routine pelvic examination in a 60-year-old asymptomatic menopausal woman with no history of hormone replacement therapy, chronic pelvic pain, infertility, or previous gynecologic surgery.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Images in Gynecologic Surgery Source Type: research
We report a case of a rectal-vaginal mass found during a routine pelvic exam in a 60-years-old asymptomatic menopausal woman, with no history of hormone replacement therapy, chronic pelvic pain, infertility or previous gynecological surgery.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: IMAGES IN Gynecological Surgery Source Type: research
Authors: Zheng W, Cao L, Xu Z, Ma Y, Liang X Abstract Endometriosis is caused by the growth or infiltration of endometrial tissues outside of the endometrium and myometrium. Symptoms include pain and infertility. Surgery and hormonal therapy are widely used in Western medicine for the treatment of endometriosis; however, the side effects associated with this practice include disease recurrence and menopause, which can severely influence quality of life. Angiogenesis is the main biological mechanism underlying the development of endometriosis. Numerous natural products and Chinese medicines with potent anti-angiogen...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 3 November 2018Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Dominique de Ziegler, Paul Pirtea, Marie Carbonnel, Marine Poulain, Ettore Cicinelli, Carlo Bulletti, Konstantinos Kostaras, George Kontopoulos, David Keefe, Jean Marc AyoubiAbstractEndometriosis – a disease causing pain and infertility – is encountered in nearly 50% of infertile women. While medical treatment is effective on pain and recurrence of symptoms after surgical excision, it is of no help for treating infertility for which the only options considered are surgery and AR...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
The objective of this study is to study effect of laparoscopy surgery vs dienogest in reducing pain and effect on infertility associated with endometriosis.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Source Type: research
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