Depression in chronic ketamine users: sex differences and neural bases

Chronic ketamine use leads to cognitive and affective deficits including depression. Here, we examined sex differences and neural bases of depression in chronic ketamine users. Compared to non-drug using healthy controls (HC), ketamine-using females but not males showed increased depression score as assessed by the Center of Epidemiological Studies Depression Scale (CES-D). We evaluated resting state functional connectivity (rsFC) of the subgenual anterior cingulate cortex (sgACC), a prefrontal structure consistently implicated in the pathogenesis of depression.

Source: Psychiatry Research: Neuroimaging - September 5, 2017 Category: Psychiatry Authors: Chiang-Shan R. Li, Sheng Zhang, Chia-Chun Hung, Chun-Ming Chen, Jeng-Ren Duann, Ching-Po Lin, Tony Szu-Hsien Lee Source Type: research