Ca2+ and mitochondrial ROS: Both hero and villain in membrane repair

Membrane repair is a symphony of signaling, conducted principally by the steep influx of Ca2+ through an injured membrane. In this issue of Science Signaling, Horn et al. reveal unique interplay between Ca2+ influx and mitochondrially generated reactive oxygen species (mtROS) to enhance actin-mediated wound closure for survival of injured mammalian muscle and nonmuscle cells.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Focus Source Type: news