Differential effects of Imipramine and CORT 118335 (Glucocorticoid receptor modulator/Mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats.

Differential effects of Imipramine and CORT 118335 (Glucocorticoid receptor modulator/Mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats. Behav Brain Res. 2017 Aug 30;: Authors: Nguyen ET, Caldwell JL, Streicher J, Ghisays V, Balmer NJ, Estrada CM, Solomon MB Abstract Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion. Glucocorticoids act on Type I mineralocorticoid (MR) and Type II glucocorticoid receptors (GR) to modulate mood and endocrine responses. Successful antidepressant treatment normalizes HPA axis function, in part due to modulatory effects on MR and GR in cortico-limbic structures. Although women are twice as likely to suffer from depression, little is known about how antidepressants modulate brain, endocrine, and behavioral stress responses in females. Here, we assessed the impact of CORT 118335 (GR modulator/MR antagonist) and imipramine (tricyclic antidepressant) on neuroendocrine and behavioral responses to restraint or forced swim stress (FST) in female rats (n=10-12/group). Increased immobility in the FST is purported to reflect passive coping or depression-like behavior. CORT 118335 dampened adrenocorticotropic hormone (ACTH) and corticosterone responses to the FST, but did not affect immobility. Imipramine suppressed ACTH, but had minimal effect...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research