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3D printed TCP-based scaffold incorporating VEGF-loaded PLGA microspheres for craniofacial tissue engineering

Vascularization is a critical process during bone regeneration/repair and the lack of tissue vascularization is recognized as a major challenge in applying bone tissue engineering methods for cranial and maxillofacial surgeries. The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/ β-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model.
Source: Dental Materials - Category: Materials Science Authors: Source Type: research

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Conclusions: Under energy balance conditions, REE increased 22 h after both moderate-intensity and high-intensity exercise. Exercise-induced muscle damage/repair and increased sympathetic tone may contribute to increased REE, whereas uncoupled phosphorylation does not. These results suggest that moderate- to high-intensity exercise may be valuable for increasing energy expenditure for at least 22 h after the exercise.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Basic Sciences Source Type: research
Hormesis is a near ubiquitous phenomenon in living organisms and their component parts: a little damage, a short or mild exposure to damaging circumstances, can result in a net benefit to health and longevity. Cells respond to damage or stress by increasing their self-repair efforts for some period of time, maintaining their function more effectively than would otherwise have been the case. At the high level, the outcomes of hormesis have been measured for a wide variety of stresses and systems, from individual cells to entire organisms. At the low level of specific biochemical processes and interaction of components insid...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
In this issue ofJAMA Facial Plastic Surgery, Christophel et al assess the value of a novel facial trauma simulation course given to 30 residents from 2 institutions. During this 1-day course, an impactor delivered a measurable force to create facial fractures in fresh frozen cadaver heads, which were then scanned with high-resolution computed tomography. Using each specimen ’s unique findings, a pair of trainees formulated and presented their theoretical treatment plan, which included airway management, fracture type, surgical approach, and type of fracture repair. Finally, the authors measured the improvement in the...
Source: JAMA Facial Plastic Surgery - Category: Cosmetic Surgery Source Type: research
Key Points Percutaneous mitral valve repair for symptomatic severe mitral regurgitation has rapidly evolved as a viable therapeutic option for high‐surgical risk patients. Both randomized clinical studies as well as real world registry data have demonstrated significant improvement in severity of MR and clinical outcomes. In carefully selected patients with severely reduced left ventricular systolic function and severe symptomatic MR, Mitraclip therapy seems to show promise.
Source: Catheterization and Cardiovascular Interventions - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Valvular and Structural Heart Diseases Source Type: research
Conclusion: Hemodialysis intensity did not predict changes in either macro- or microvascular parameters. Inflammation mediated through the IL-8 pathway predicted microvascular injury while Flt-1, a potential marker of angiogenesis and endothelial repair, might have a significant protective role. Further understanding of these pathways will be necessary to improve dialysis outcomes.Kidney Blood Press Res 2017;42:905 –918
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
This study aimed to evaluate the anticancer activity of CEP in p53 mutant versus p53 wild-type colorectal cancer cells and determine its underlying mechanisms of action. Our results showed that CEP induced colorectal cancer cell death in a concentration-dependent manner. Remarkably, CEP was more effective in controlling the growth of the p53 mutant colorectal cancer cell lines, HT‑29 and SW-620, than the p53 wild-type colorectal cancer cell lines, COLO‑205 and HCT-116. Further studies on the underlying mechanisms revealed that CEP could induce cell cycle arrest and apoptosis in both HT‑29 and COLO‑205 cells. Treatm...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Should James Clement's name remain well-known in association any of the present day work on human longevity, one would hope it will be as one of the pioneers to first organize trials of senolytic therapies in humans, via his Betterhumans organization. This is far from the only research interest of this citizen scientist, however, and in past years he has put in a great deal of time and effort to expand what is known of the genetics and biochemistry of supercentenarians, rare individuals who survive past the age of 110. That is the focus of the article here. For my part I think that the genetics of supercentenarians ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
The Cartiva implant (Cartiva, Alpharetta, GA) is an exciting option in dramatically diminishing patient symptoms in advanced stages of hallux rigidus as well as allowing continued joint motion. The procedure does not burn many bridges in case a future revision to an arthrodesis is necessary. This advantage is in contradistinction to other current implants whereby more bone resection is required for implant placement.
Source: Clinics in Podiatric Medicine and Surgery - Category: Podiatry Authors: Source Type: research
No abstract available
Source: Annals of Surgery - Category: Surgery Tags: Letters to the Editor Source Type: research
No abstract available
Source: Annals of Surgery - Category: Surgery Tags: Letters to the Editor Source Type: research
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