3D printed TCP-based scaffold incorporating VEGF-loaded PLGA microspheres for craniofacial tissue engineering

Vascularization is a critical process during bone regeneration/repair and the lack of tissue vascularization is recognized as a major challenge in applying bone tissue engineering methods for cranial and maxillofacial surgeries. The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/ β-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model.
Source: Dental Materials - Category: Materials Science Authors: Source Type: research

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This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 25 May 2018 Source:Biochimica et Biophysica Acta (BBA) - Reviews on Cancer Author(s): Yaqin Shi, Fang Yang, Doudou Huang, Xiaoxiang Guan Androgen receptor (AR) targeted treatment has shown promising preliminary results in triple negative breast cancer (TNBC). Identification of AR-associated signaling pathways is of great significance for in-depth understanding of their roles in pathogenesis of TNBC. To meet this objective, preclinical and clinical studies were conducted to clarify the biological interactions of AR signaling and combination strategies based on AR-targeted therapy. Biologi...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
In this study, four cDNA libraries were constructed with the body wall from healthy and three SUS-infected stages of A. japonicus. A total of 248 conserved miRNAs and five novel miRNAs were identified through Illumina HiSeq 2000 platform. Compared to the control, 238 miRNAs showed significant differential expression at three stages of SUS progression. Totally, 3149 miRNA-mRNA pairs were identified by target prediction and 314 miRNA-mRNA pairs showed negative correlation. It is noteworthy that 15 miRNAs and four mRNAs were located at the crucial positions of the network built with the anti-correlated miRNA-mRNA pairs. GO an...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: June 2018 Source:Journal of Microbiological Methods, Volume 149 Author(s): D.I. Ayala, J.C. Chen, M. Bugarel, G.H. Loneragan, H.C. den Bakker, K.R. Kottapalli, M.M. Brashears, K.K. Nightingale Lactobacillus animalis NP51 is a direct-fed microbial strain (DFM) extensively used as a pre-harvest food safety mitigation in feedlot cattle due to its antagonistic effects against human foodborne pathogens such as Salmonella and Escherichia coli O157:H7. NP51 not only promotes overall gut health but interferes with the ability of these pathogens to colonize the gastrointestinal tract of cattle. As a result, NP51 ...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Int J Angiol DOI: 10.1055/s-0038-1649512Aortic arch surgery is a technical challenge, and cerebral protection during distal anastomosis is a continued topic of controversy and discussion. The physiologic effects of hypothermic arrest and adjunctive cerebral perfusion have yet to be fully defined, and the optimal strategies are still undetermined. This review highlights the historical context, physiological rationale, and clinical efficacy of various neuroprotective strategies during arch operations. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents&nb...
Source: International Journal of Angiology - Category: Cardiology Authors: Tags: Review Article Source Type: research
THE FIRST human trials of a ground-breaking drug shown to repair DNA damage that contributes to Alzheimer ’s disease will be launched this week, in a move scientists hope could lead to a cure. The study, being launched in the UK, and hospitals in France and Spain, will, for the first time, see the neuro-degenerative condition treated with an agent which acts as a DNA repair kit to restore memory and r everse behavioural changes such as aggression and social avoidance.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
DISCUSSION: Tramadol can ameliorate the histopathological structure of ischaemic tissue in both periods of I/R injury in rat. We suggest further research investigating various dosages with different administration methods of tramadol in stroke should be conducted by adopting different explorative techniques. PMID: 29792388 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Conclusions: Higher psychological and physical well-being was observed in the experimental group as compared with the control group (P
Source: Implant Dentistry - Category: Dentistry Tags: Basic and Clinical Research Source Type: research
Conclusion: The use of L-PRF associated with collagen membrane was efficient for the sealing of the sinus membrane perforation and enabled bone formation for subsequent implant installation.
Source: Implant Dentistry - Category: Dentistry Tags: Clinical Science and Techniques Source Type: research
Conclusions B. monneiri extracts may have utility in treatment of colorectal cancers that exhibit deficiency in ERCC4 (XPF). Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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