3D printed TCP-based scaffold incorporating VEGF-loaded PLGA microspheres for craniofacial tissue engineering
Vascularization is a critical process during bone regeneration/repair and the lack of tissue vascularization is recognized as a major challenge in applying bone tissue engineering methods for cranial and maxillofacial surgeries. The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/ β-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model.
Conclusion: Our results demonstrated that shikonin induced the recovery of tissue repair and motor function via inactivation of HMGB1/TLR4/NF- κB signaling pathway in SCI model of rats. Meanwhile, shikonin regulated the inflammation response in SCI by suppressing the HMGB1/TLR4/NF-κB signaling pathway. The described mechanism sheds novel light on molecular signaling pathway in spinal cord injury and secondary injury including inflammator y response.Cell Physiol Biochem 2017;43:481 –491
Abstract: Cellular therapy with CD4+FOXP3+ T regulatory (Treg) cells is a promising strategy to induce tolerance after solid-organ transplantation or prevent graft-versus-host disease after transfer of hematopoietic stem cells. Treg cells currently used in clinical trials are either polyclonal, donor- or antigen-specific. Aside from variations in isolation and expansion protocols, however, most therapeutic Treg cell-based products are much alike. Ongoing basic science work has provided considerable new insight into multiple facets of Treg cell biology, including their stability, homing, and functional specialization; integ...
Background: Postoperative damage of the urethral rhabdosphincter and nerve-vascular networks is a major complication of radical prostatectomy and generally causes incontinence and/or erectile dysfunction. The human skeletal muscle-derived stem cells, which have a synchronized reconstitution capacity of muscle-nerve-blood vessel units, were applied to this damage. Methods: Cells were enzymatically extracted from the human skeletal muscle, sorted using flow cytometry as CD34+/45− (Sk-34) and CD29+/34−/45− (Sk-DN/29+) fractions, and separately cultured/expanded in appropriate conditions within 2 weeks. Uret...
CONCLUSIONS: The operation method used in this study demonstrated to be a safe and reliable procedure producing a very good flap blood supply as well as excellent sensory recovery and satisfactory postoperative appearance. PMID: 28925493 [PubMed - in process]
This study aims to evaluate the differences in outcomes among surgeons who routinely use either suprarenal or infrarenal fixation, as well as all surgeons in the Vascular Study Group of New England (VSGNE).
Use of vascular closure devices has a low rate of bleeding complication, device failure, and need for operative repair. Bleeding is associated with increased age, interventional procedure, and end-stage renal disease. Mynx, Perclose, and Angio-Seal have similar rates of complications. Use of these devices are a safe option for groin vessel closure.
EndoAnchors (Medtronic, Santa Rosa, Calif) have shown safety and efficacy in maintaining proximal seal and in treatment of type I endoleaks. The Aneurysm Treatment Using the Heli-FX Aortic Securement System Global Registry (ANCHOR) data captured use of a variety of endografts with infrarenal (IR) and suprarenal (SR) fixation; approximately 75% of patients were considered to have one or more markers for hostile aortic neck anatomy. The outcomes of the EndoAnchor endovascular aneurysm repair (EVAR) with IR and SR stent grafts were analyzed.
Fenestrated/branched endovascular aneurysm repair (FEVAR) is the highest radiation dose procedure performed by vascular surgeons. We sought to characterize the radiation dose to patients and staff during FEVAR procedures with different premanufactured devices.
This study assessed long-term survival after acute uncomplicated type B dissection comparing medical therapy (MED), open repair (OPEN), and TEVAR.
This study investigated whether IBD is superior to HAE in 30-day outcomes of patients with elective endovascular aneurysm repair (EVAR) using the multicenter prospectively collected American College of Surgeons National Surgical Quality Improvement Program database.