Efficacy of single or combined midodrine and pyridostigmine in orthostatic hypotension

Conclusions:
Single or combination treatment with midodrine and pyridostigmine was effective and safe in patients with OH for up to 3 months. Midodrine was better than pyridostigmine at improving OH-related symptoms.

Clinicaltrials.gov identifier:
NCT02308124.

Classification of evidence:
This study provides Class IV evidence that for patients with neurogenic OH, long-term treatment with midodrine alone, pyridostigmine alone, or both midodrine and pyridostigmine is safe and has similar effects in improving orthostatic BP drop up to 3 months.

Source: Neurology - September 4, 2017 Category: Neurology Authors: Byun, J.-I., Moon, J., Kim, D.-Y., Shin, H., Sunwoo, J.-S., Lim, J.-A., Kim, T.-J., Lee, W.-J., Lee, H. S., Jun, J.-S., Park, K.-I., Lee, S.-T., Jung, K.-H., Jung, K.-Y., Lee, S. K., Chu, K. Tags: Autonomic diseases, All Clinical trials, Class IV ARTICLE Source Type: research