Medical News Today: Cancer: Existing drug may prevent treatment-induced infertility

Researchers have found that a drug once tested as an anti-cancer treatment may actually help to prevent female infertility caused by cancer radiotherapy.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

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When thinking of the great men and women of urology, one might consider the early pioneers in treatment of stones, voiding dysfunction, infertility, or cancer. Throughout history, urologists have also been technological leaders and have been at the cutting edge of medicine and public health. One such leader, Walter D. Greene, emerged in the “Queen City” of Buffalo, New York at the turn of the 20th century, when one of the most serious issues facing American cities was the outbreak of venereal and infectious diseases.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Conclusion: The results of this study did not find any established evidence that fertility medications affect the risk of cancer among users. In conclusion, the relationship between infertility treatment and cancer incidence remains an open question.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionsIt is safe and effective for early-stage patients with cervical cancer whose lesions are less than 2  cm to receive RVT. For those patients with lesions 2–4 cm who desire fertility preservation and without any evidence of infertility, RAT can be a feasible alternative to RH under fully informed consent. However, more CCTs with larger sample size are still required for further validation.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Abstract While radiotherapy is widely used in cancer treatment, the benefits can be limited by radiation-induced damage to neighboring healthy tissues. We previously demonstrated that the anti-inflammatory compound dimethylaminoparthenolide (DMAPT) selectively induces radiosensitivity in prostate tumor tissue from transgenic adenocarcinoma of mouse prostate (TRAMP), while simultaneously protecting healthy tissues from 6 Gy whole-body radiation-induced apoptosis. Here, we examined the radioprotective effect of DMAPT on fibrosis in normal tissues after a partial-body fractionated radiation protocol that more closely...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
What do you have in common with rodents, birds, and reptiles? A lot more than you might think. These creatures have organs and body systems very similar to our own: a skeleton, digestive tract, brain, nervous system, heart, network of blood vessels, and more. Even so-called “simple” organisms such as insects and worms use essentially the same genetic and molecular pathways we do. Studying these organisms provides a deeper understanding of human biology in health and disease, and makes possible new ways to prevent, diagnose, and treat a wide range of conditions. Historically, scientists have relied on a few k...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Genes Biofilms Cool Creatures Diseases Evolution Modeling Neurobiology Regeneration Research Organisms Wound Healing Source Type: blogs
ConclusionsIn a sample of women's health providers across multiple different OB/GYN specialties, there was an overall supportive response towards PGT use for a variety of common indications. Infertility specialists were the most supportive of PGT use, which may reflect the familiarity these providers have with this procedure. There was an overwhelmingly non-supportive response to the use of PGT for non-disease related indications. The percentage of medical professionals working in women's health without prior knowledge of PGT (22.5%) is higher than expected, identifying the need for more education regarding the availabilit...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
CONCLUSION: The era of total orchiectomy for any uncertain testicular lesion is over. We try the challenge of characterization, and define management's algorithms based on clinical biological data and suspected nature of the tumor at imaging. PMID: 31088679 [PubMed - as supplied by publisher]
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research
Abstract Endometriosis, a common gynecological disease, is associated with pelvic pain and infertility. Endometriosis affects approximately 10% of women, but that number increases to 30-50% in symptomatic premenopausal women. Despite the prevalence of endometriosis, the cause has yet to be fully elucidated. Recent study of the molecular pathways of endometrial cancer has brought the long non-coding RNA (lncRNA) H19 to our attention. In this paper, we explored the role of lncRNA-H19 in endometrial tissue proliferation. We found that ectopic endometrial cells taken from women with endometriosis showed elevated level...
Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research
A new report from the Environmental Working Group has found that 610 locations in 43 US states contain unsafe levels of PFAS chemicals, which have been linked to birth defects and cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsWe recommend developing collaborative initiatives to build a regional repository of systematically assessed health outcomes and biospecimens to investigate treatment, social-environmental and genetic predictors, and interventions for late effects in this population.Implications for Cancer SurvivorsThe existing types of chronic health problems identified in this review suggest the need for active screening, better access to survivorship care, and promotion of protective health behavior in Asia.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
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