Retrospective analysis of treatments with recombinant FSH and recombinant LH versus human menopausal gonadotropin in women with reduced ovarian reserve

In this study, we compared retrospectively two regimens, r-FSH/r-LH and hMG, for the treatment of women with reduced ovarian reserve, identified as subjects with antral follicle count (AFC)
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research

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Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in patients with poor ovarian response undergoing in vitro fertilization/intracytoplasmic sperm injection with a gonadotropin-releasing hormone antagonist protocol, although significantly higher serum insulin-like growth factor-1 level and insignificantly lower serum insulin-like growth factor binding protein-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment. (Curr Ther Res Clin Exp. 2020; 81:XXX–XXX)
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
Objective: To compare the effects of letrozole and human menopausal gonadotropin (HMG) in the treatment of patients with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC). Methods: A total of 96 clomiphene resistance polycystic ovary syndrome patients infertility were randomly divided into an LE group, and HMG group (n = 48). LE group orally received letrozole at 5.0 mg/d−1 on the 3rd–5th days of menstrual cycle for 5 consecutive days, and 75 U/d−1 HMG was given through intramuscular injection for 5 days starting from the third day of menstrual cycle in HMG group. Number o...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in POR patients undergoing IVF/ISCI with a GnRH antagonist protocol, although significantly higher serum IGF-1 level and insignificantly lower serum IGFBP-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
The North American Menopause Society (NAMS) held the 2018 Utian Translational Science Symposium on October 2, 2018, in San Diego, California, to discuss new therapeutic approaches to uterine leiomyomas when surgery is not the optimal choice. Uterine leiomyomas arise from a single clonal cell and are the most common gynecologic disorder affecting reproductive and perimenopausal women worldwide. The prevalence of this disorder is approximately 40% to 70% in white women and 60% to 80% in black women. Recent research suggests that both estrogen and progesterone modulate the growth of leiomyomas, with progesterone being a majo...
Source: Menopause - Category: OBGYN Tags: NAMS Translational Science Symposium Report Source Type: research
CONCLUSIONS: There may be little or no difference in live birth, incidence of multiple pregnancy, clinical pregnancy rate, or miscarriage rate between urinary-derived gonadotrophins and recombinant follicle stimulating hormone in women with polycystic ovary syndrome. For human menopausal gonadotropin or highly purified human menopausal gonadotrophin versus urinary follicle stimulating hormone we are uncertain whether one or the other improves or lowers live birth, incidence of multiple pregnancy, clinical pregnancy rate, or miscarriage rate. We are uncertain whether any of the interventions reduce the incidence of ova...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
In the U.S., two-thirds of people with Alzheimer’s disease are women, according to the Alzheimer’s Association. For decades, experts have explained the gender divide by the fact that women also tend to live longer than men, and the biggest risk factor for Alzheimer’s is age. “Everyone brushed it off to the fact that women were living longer,” says Rachel Whitmer, professor of epidemiology at University of California Davis. “Now science is saying, wait, that’s not the end of the story.” Pregnancy, according to two of the latest studies on the issue, may have something to do wi...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Brain healthytime Source Type: news
Conclusions Except for the risk of premature ovarian failure, a rare adverse effect of combined treatments, both single-agent and multiagent chemotherapy can be safely administered to patients with a desire for childbearing. High-risk patients have worse reproductive outcomes because they undergo hysterectomy more frequently than low-risk patients.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Gestational Cancer Source Type: research
Conclusion(s) Letrozole-low dose gonadotropins combination appears to be effective across different causes of infertility for superovulation. The letrozole-low dose gonadotropin combination resulted in high rate of monofolliculogenesis, low occurrence of multiple gestations and no case of OHSS or cycle cancellation.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusions: Using IVF to investigate human reproduction and pregnancy outcomes, we found that concentrations of some urinary PFR metabolites were negatively associated with proportions of successful fertilization, implantation, clinical pregnancy, and live birth. https://doi.org/10.1289/EHP1021 Received: 26 August 2016 Revised: 10 April 2017 Accepted: 02 June 2017 Published: 25 August 2017 Address correspondence to C. Carignan, Department of Environmental Health, Building 1, 14th Floor, 665 Huntington Avenue, Boston, MA 02115 USA. Phone: (617) 432-4572. Email: carignan@hsph.harvard.edu Supplemental Material is avail...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
In the past decades understanding of sex-related differences in the presentation of cardiovascular disease (CVD) has improved. Conditions leading to alterations in estrogen level such as menopause and polycystic ovary syndrome are associated with increased risk of CVD [1]. Studies have found that a history of recurrent miscarriages [2], gestational diabetes mellitus (GDM) [3] and pregnancy-induced hypertension [4] were associated with an increased risk of CVD. Some conditions such as Raynaud ’s phenomenon and migraine are found to have a female preponderance and further, migraine has been linked to increased cardiova...
Source: Maturitas - Category: Primary Care Authors: Source Type: research
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