A specific pattern of gray matter atrophy in Alzheimer's disease with depression - Karavasilis E, Parthimos TP, Papatriantafyllou JD, Papageorgiou SG, Kapsas G, Papanicolaou AC, Seimenis I.

Considering the high incidence of depressive symptoms in Alzheimer's disease (AD), we conducted a large-sample study to investigate the pattern of gray matter (GM) abnormalities that differentiates depressive from non-depressive AD patients. We included 20...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Related Links:

I'm pleased to note that the Methuselah Fund has closed its first fundraising effort after hitting the target amount, obtaining the support of many long-standing members of our community. The fund is a mixed for-profit/non-profit vehicle that is intended to expand the investment efforts undertaken by the Methuselah Foundation in past years, helping promising lines of rejuvenation research to make the leap from laboratory to commercial development. At the present point in time there are few enough rejuvenation focused companies that doing this well requires extensive connections within the research community, and a willingn...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs
DiscussionOur theory-based intervention makes use of real-world applicable approaches in a novel and innovative way to change the paradigm of how we currently look at acute care and post-acute transitions in persons with ADRD.Trial registrationClinicalTrials.gov, ID:NCT03046121. Registered on 8 February 2017.
Source: Trials - Category: Research Source Type: clinical trials
Molecules, Vol. 23, Pages 2375: Targeted Neurotransmitters Profiling Identifies Metabolic Signatures in Rat Brain by LC-MS/MS: Application in Insomnia, Depression and Alzheimer’s Disease Molecules doi: 10.3390/molecules23092375 Authors: Huarong Xu Zhenru Wang Lin Zhu Zhenyu Sui Wenchuan Bi Ran Liu Kaishun Bi Qing Li Epidemiological, cross-sectional, and prospective studies have suggested that insomnia, Alzheimer’s disease (AD) and depression are mutually interacting conditions and frequently co-occur. The monoamine and amino acid neurotransmitter systems in central nervous system were ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 14 September 2018Source: NeuroImageAuthor(s): Matthew Leming, Li Su, Shayanti Chattopadhyay, John SucklingAbstractFunctional connectivity is frequently derived from fMRI data to reduce a complex image of the brain to a graph, or "functional connectome". Often shortest-path algorithms are used to characterize and compare functional connectomes. Previous work on the identification and measurement of semi-metric (shortest circuitous) pathways in the functional connectome has discovered cross-sectional differences in major depressive disorder (MDD), autism spectrum disorder (ASD), a...
Source: NeuroImage - Category: Neuroscience Source Type: research
The presence of psychiatric issues in dementia is not a recent discovery. Over a century ago, Alois Alzheimer described prominent psychotic symptoms in the first recorded case of Alzheimer's disease (AD).1 The hypernym, ‘behavioral and psychological symptoms of dementia’ (BPSD) only emerged within the past two decades due to increasing recognition that psychiatric symptoms and behaviors that occur in dementia are important targets for intervention.1 Rather than a precise definition, BPSD subsumes numerous mood and behavior symptoms with no assumptions about the etiology.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: INVITED PERSPECTIVE Source Type: research
(MedPage Today) -- News and commentary from the psychiatry world
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
Research into cellular senescence is at present one of the most exciting areas of the science of aging, as it is in this part of the scientific community that the first real, actual, legitimate rejuvenation therapies were discovered. These senolytic treatments, capable of selectively destroying senescent cells, are now in the process of verification in human trials. They offer the possibility of significant reversal of all inflammatory age-related disease, to a far greater degree than can be offered by any past therapy: osteoporosis; the fibrosis that drives dysfunction of the lung, heart, and kidney; neurodegenerative con...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Authors: Lauriola M, Mangiacotti A, D'Onofrio G, Cascavilla L, Paris F, Ciccone F, Greco M, Paroni G, Seripa D, Greco A Abstract BACKGROUND/AIM: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up. METHODS: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. RESULTS: The risk to develop AD, w...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Abstract Traumatic brain injury (TBI) is the main reason of lifelong disability and casualty worldwide. In the United state alone, 1.7 million traumatic events occur yearly, out of which 50,000 results in deaths. Injury to the brain could alter various biological signaling pathways such as excitotoxicity, ionic imbalance, oxidative stress, inflammation, and apoptosis which can result in various neurological disorders such as Psychosis, Depression, Alzheimer disease, Parkinson disease, etc. In literature, various reports have indicated the alteration of these pathways after traumatic brain injury but the exact mech...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
More News: Alzheimer's | Depression | Papanicolaou (Pap) Smear | Study