Pancreas Bifidum With Acute Necrotizing Pancreatitis Pancreas Bifidum With Acute Necrotizing Pancreatitis
Learn about pancreas bifidum, a rare foregut anomaly, in this unusual case. Does having a bifid pancreas predispose to development of acute pancreatitis?Applied Radiology
ConclusionThe DPP-IV Inhibitory activity of Terminalia arjuna was found to be comparable to Vildagliptin. The DPP-IV Inhibitory activity translated into significant cardioprotective effects in the setting of diabetes. The active ingredient of Terminalia arjuna; Arjunetin, Arjungenin, Ellagic acid and Arjunic acid showed superior DPP-IV inhibitory activity as compared to synthetic DPP-IV inhibitors (Sitagliptin and Vildagliptin).Graphical abstract
Publication date: November 2018Source: Biomedicine &Pharmacotherapy, Volume 107Author(s): Tao Wang, Lihua Jiang, Xiaoyong Wei, Bo Liu, Junbo Zhao, Peilin Xie, Bo Yang, Lijuan WangAbstractTo evaluate the expression and effect of miR-21-3p in pancreas and lung injury of acute hemorrhagic necrotizing pancreatitis (AHNP) rats. AHNP rat model was constructed via retrograde injection of 5% sodium taurocholate into biliary pancreatic duct. Then rats were divided into normal, sham, AHNP, mimics negative control (NC), miR-21-3p mimics, inhibitors NC, miR-21-3p inhibitors, miR-21-3p mimics + phosphate buffer saline...
For generations, freshly minted surgical residents heard the advice: “eat when you can, sleep when you can…and don’t mess with the pancreas.” Times have changed. Gastroenterologists, interventional endoscopists, and surgeons have learned how to diagnose and treat benign pancreatic diseases with remarkable success. This issue of Gastrointestinal Endoscopy Clin ics of North America highlights interventions using endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and treatment of recurrent acute pancreatitis, autoimmune pancreatitis, and pancreatic cyst drainage.
The management of benign pancreatic diseases is one of the more difficult clinical problems that the practicing gastroenterologist faces. The management of acute and chronic pancreatitis and autoimmune pancreatitis and the evaluation and surveillance of incidentally found pancreatic cysts can be particularly vexing. Due to the relative scarcity of these conditions relative to the more common gastrointestinal problems, management of these clinical scenarios can be overwhelming for those who are not accustomed to these diseases.
Individuals with acute recurrent and chronic pancreatitis may have an inherited predisposition to the development of the disease. Pancreatitis in the setting of a significant family history of the disease can be classified as hereditary or familial pancreatitis. In this article, the authors closely examine the specific genes implicated in pancreatitis, investigate the role of genetic testing for diagnosis, and describe the impact of genetic testing results on clinical management.
Pancreatitis remains the most common and potentially devastating complication of endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Recent advances in prophylaxis have improved but not eliminated this problem, underscoring the importance of ongoing research toward this goal. This review aims to provide an evidence-based approach to post-ERCP pancreatitis prevention through patient selection, risk stratification, procedural technique, and multimodality prophylaxis, and discusses ongoing and future research initiatives in this important area.
ConclusionWith a focused approach and appropriate investigations, the etiology of RAP can be identified in a significant proportion of patients. Therapeutic options are limited and future research is needed to improve understanding of the disease.
Conclusions: We suggest that BISAP and PANC3 be obtained within the initial 24 h of hospitalization to offer an early prediction of length of stay and ICU admission. Subsequently, RAC and DBC can offer further information later in the course of the disease.Digestion
Journal of Gastroenterology and Hepatology, EarlyView.