Check point inhibitors as therapies for infectious diseases.
Check point inhibitors as therapies for infectious diseases.
Curr Opin Immunol. 2017 Aug 30;48:61-67
Authors: Cox MA, Nechanitzky R, Mak TW
Abstract
The recent successes of immune check point targeting therapies in treating cancer patients has driven a resurgence of interest in targeting these pathways in chronically infected patients. While still in early stages, basic and clinical data suggest that blockade of CTLA-4 and PD-1 can be beneficial in the treatment of chronic HIV, HBV, and HCV infection, as well as other chronic maladies. Furthermore, novel inhibitory receptors such as Tim-3, LAG-3, and TIGIT are the potential next wave of check points that can be manipulated for the treatment of chronic infection. Blockade of these pathways influences more than simply T cell responses, and may provide new therapeutic options for chronically infected patients.
PMID: 28865357 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Cox MA, Nechanitzky R, Mak TW Tags: Curr Opin Immunol Source Type: research