Outcome Analysis of Pediatric ALL Patients Treated with TBI-Free Allogeneic Hematopoietic Stem Cell Transplantation: Comparison of Patients with and Without Central Nervous System Involvement

• Younger acute lymphoblastic leukemia (ALL) patients were at increased risk for CNS involvement.• Allogeneic hematopoietic stem cell transplantation (HSCT) using a non-total body irradiation (TBI) conditioning regimen led to similar early and long-term outcomes for pediatric ALL patients with a nd without central nervous system (CNS) involvement.• Having similar results compared with other studies using a TBI-based allogeneic HSCT on ALL patients with CNS involvement, a TBI-free allogeneic HSCT seems to be feasible and effective for CNS involved ALL patients.

Source: Biology of Blood and Marrow Transplantation - September 1, 2017 Category: Hematology Authors: Amir Ali Hamidieh, Seyed Mostafa Monzavi, Maryam Kaboutari, Maryam Behfar, Mohsen Esfandbod Source Type: research