Activated Notch signaling cascade is correlated with stem cell differentiation toward absorptive progenitors after massive small bowel resection in a rat

In conclusion, 2 wk after bowel resection in rats, stimulated Notch signaling directs the crypt cell population toward absorptive progenitors. NEW & NOTEWORTHY This study provides novel insight into the mechanisms of cell proliferation following massive small bowel resection. We show that 2 wk after bowel resection in rats, enhanced stem cell activity was associated with stimulated Notch signaling pathway. We demonstrate that activated Notch signaling cascade directs the crypt cell population toward absorptive progenitors.

http://ajpgi.physiology.org/cgi/content/abstract/313/3/G247?rss=1

Source: AJP: Gastrointestinal and Liver Physiology - September 1, 2017 Category: Gastroenterology Authors: Sukhotnik, I., Coran, A. G., Pollak, Y., Kuhnreich, E., Berkowitz, D., Saxena, A. K. Tags: RESEARCH ARTICLE Source Type: research