Low incidence of coaggregation amongst bacteria isolated from the upper respiratory tract in health and disease.

Low incidence of coaggregation amongst bacteria isolated from the upper respiratory tract in health and disease. J Med Microbiol. 2017 Aug 31;: Authors: Humphreys GJ, Kumar N, McBain AJ Abstract The nasal cavity harbours a commensal microbiota that reportedly provides colonization resistance against respiratory pathogens. Following the onset of chronic rhinosinusitis (CRS), a change in sinus microbiota composition is frequently reported in which atypical anaerobic and/or Gram-negative bacteria predominate. We have investigated pairwise interactions between respiratory bacteria isolated from healthy adults (n=3) and individuals exhibiting CRS (n=3). Antagonism was determined using a spot plate methodology and coaggregation scores were determined using a quantitative spectrophotometric assay. Obligate anaerobes were isolated from all CRS samples and exhibited inter-host growth inhibition of commensal nasal bacteria, including Corynebacterium spp. and Staphylococcus spp. Antagonism between bacteria isolated from healthy individuals was limited to corynebacterial-mediated inhibition of the staphylococci. The frequency of coaggregation was low overall (2/153 pairwise interactions). Antagonism of the nasal microbiota by respiratory pathogens may represent a competitive strategy in the sinus and warrants further investigation. PMID: 28857734 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research