Modelling the neuromotor abnormalities of psychotic illness: Putative mechanisms and systems dysfunction

Limitations in access to antipsychotic-na ïve patients and in the incisiveness of studies that can be conducted on them, together with the inevitability of subsequent antipsychotic treatment, indicate an enduring role for animal models that can inform on the pathobiology of neuromotor abnormalities in schizophrenia and related psychotic il lness. This review focusses particularly on genetically modified mouse models that involve genes associated with risk for schizophrenia and with mechanisms implicated in the neuromotor abnormalities evident in psychotic patients, as well as developmental models that seek to mirror the trajectory, ph enomenology and putative pathophysiology of psychotic illness.
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research