Cerebrospinal fluid CXCL13 as a diagnostic marker of neuroborreliosis in children: a retrospective case-control study

Lyme neuroborreliosis (LNB) is a frequent manifestation of Lyme disease in children and its current diagnosis has limitations. The elevation of the chemokine CXCL13 in the cerebrospinal fluid (CSF) of adult pa...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research

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Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Current Abstracts Source Type: research
In this study, we used PCR-based methods to provide the first evidence of Borrelia burgdorferi sensu lato (s.l.) infections in the three bat-associated tick species collected from ten bat species sampled in Poland and Romania. B. burgdorferi s.l. was detected in 24% (64/266) of tick samples, and 40.3% (60/149) of the bats carried infected chiropterophilic ticks.In Poland, the B. burgdorferi s.l. infection prevelance of I. ariadnae ticks parasitizing Myotis species was four times higher compared to the I. vespertilionis ticks derived from Rhinolophus hipposideros bats (44.4% vs.10%, respectively). The observed differences i...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
A basic feature of infection caused by Borrelia burgdorferi, the etiological agent of Lyme borreliosis, is that persistent infection is the rule in its many hosts. The ability to persist and evade host immune clearance poses a challenge to effective antimicrobial treatment. A link between therapy failure and the presence of persister cells has started to emerge. There is growing experimental evidence that viable but noncultivable spirochetes persist following treatment with several different antimicrobial agents. The current study utilized the mouse model to evaluate if persistence occurs following antimicrobial treatment ...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
Semin Neurol 2019; 39: 440-447 DOI: 10.1055/s-0039-1692143Tick-borne infections—including tick-borne encephalitis viruses, represented in the United States by rare infections with Powassan and deer tick viruses, and more often Lyme disease—are of increasing importance to neurologists. Lyme neuroborreliosis (LNB) causes all or part of a triad including meningitis, radiculoneuritis, and cranial neuritis. Rarely, parenchymal brain and spinal cord involvement occur, with focal findings on examination and magnetic resonance imaging (MRI). LNB diagnosis requires plausible exposure, objective evidence of nervous syste...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
Authors: Brodziński S, Nasierowski T Abstract In the second part of the article case reports of three patients were presented. All patientswere treated for Borrelia infection and all of them developed psychotic disorders. History of each patient was different, as well as the probability of causal relationship between neuroborreliosis and psychosis. The first case concerns a female patient with no former psychiatric history, who developed psychotic episode secondary to neuroborreliosis. Psychotic disorders resolved after antibiotic treatment. In the second case, a male patient was previously twice hospitalized in p...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Brodziński S, Nasierowski T Abstract Borreliosis is a multisystem, bacterial, zoonotic infectious disease with diversified spectrumof symptoms, which may also include psychotic disorders. Clinical picture of the disease is often unspecific, which makes the diagnosis relatively difficult. Uncharacteristic process of borreliosis is a result of complex molecular strategies used by spirochetes to infect, disseminate and survive in host organism. Part I of the article is focused on the current knowledge about pathogenesis of Lyme Borreliosis (LB), especially neuroborreliosis. Additionally, epidemic situation i...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Four existing laboratory tests used to confirm a clinical diagnosis of Lyme disease recently received FDA market clearance for new testing indications that may help streamline the diagnostic process.
Source: JAMA - Category: General Medicine Source Type: research
Publication date: Available online 14 September 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Howard S. Ginsberg, Eric L. Rulison, Jasmine L. Miller, Genevieve Pang, Isis M. Arsnoe, Graham J. Hickling, Nicholas H. Ogden, Roger A. LeBrun, Jean I. TsaoAbstractIxodes scapularis is the primary vector of Lyme disease spirochetes in eastern and central North America, and local densities of this tick can affect human disease risk. We sampled larvae and nymphs from sites in Massachusetts and Wisconsin, USA, using flag/drag devices and by collecting ticks from hosts, and measured environmental variables to evaluate the enviro...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Three medical stories that we didn't cover, explained.Medscape
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Family Medicine/Primary Care Article Source Type: news
ConclusionsC. burnetii is rarely transmitted by ticks, but we proved that it is present in the environment, so it may be a danger to humans. The most common co-occurrence after tick bite concernsC. burnetii andB. burgdorferi.
Source: Infection - Category: Infectious Diseases Source Type: research
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