JAK2 V617F Acute Lymphoblastic Leukemia Secondary to Myeloproliferative Neoplasms (MPNs) or After Lenalidomide Exposure: Case Report and Review of the Literature

MPNs almost always transform to acute myeloid leukemia (AML). Delhommeau and colleagues studied the presence of the JAK2 V617F mutation in circulating B-, T- and natural killer (NK) cells of patients with PV and PMF, and detected it in B- and NK cells from approximately half their patients with PMF and a minority of those with PV.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research