Detection of Leukemia-Associated Immunophenotypic Profiles at Variable Frequencies in Healthy Donors Bone Marrow Specimens

The identification of leukemia-specific immunophenotypic profiles (LAIPs) constitutes the fundament of minimal residual disease monitoring by flow-cytometry in acute myeloid leukemia. Such MRD monitoring strategy is applicable to virtually all AML patients with satisfactory sensibility (up to 10-4) but requires a high degree of expertise. Moreover, the actual leukemia-specificity of LAIPs has never been systematically questioned. We tried to address this issue by performing a comprehensive LAIP screening in bone marrow specimens from 12 healthy controls.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research