Upregulation of MCL-1 through MAPK Activation Maintaining Mitochondrial Oxidative Phosphorylation Confers Acquired Resistance to BCL-2 Inhibitor Venetoclax in AML

In this study, we investigated mechanisms of acquired resistance to venetoclax in preclinical AML models.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: Qi Zhang, Lina Han, Ce Shi, Rodrigo Jacamo, Rongqing Pan, Ma Man Chun John, Ryan Jeremy, Stephen Kurtz, Hong Mu, Vivian Ruvolo, Helen Ma, Michael Andreeff, Yingchang Mi, Jeferrey Tyner, Joel Leverson, Anthony Letai, Richard Eric Davis, Marina Konopleva Source Type: research