Novel Complex I inhibitor IACS-010759 Targets Leukemia Initiating Cells (LICs) in AML Patients

Metabolic alterations in cancer have attracted interest as a therapeutic target. Recent studies showed that leukemia initiating cells (LICs) are highly dependent on oxidative phosphorylation (OxPhos).

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: Natalia Baran, Lina Han, Shelley Herbrich, Shannon Renee Sweeney, Alessia Lodi, Jason Gay, Ningping Feng, Jennifer R. Molina, Marcin Kaminski, Monica L. Guzman, Gheath Al-Atrash, Stefano Tiziani, Joseph R. Marszalek, Marina Konopleva Source Type: research