The Correlation between CD44 and Atypical Monoclonal Proteins in Multiple Myeloma

Multiple Myeloma (MM) is a clonal disorder of plasma cells that originates in the bone marrow. Annual incidence of MM in Armenian population is 4 from 100000 people. Interleukin-6 (IL-6) is the major survival and growth factor for myeloma cells (MC). IL-6 promotes the proliferation of human MC and prevents apoptosis of it. However, IL-6 alone is not sufficient to ensure MC survival. It is dependent on many factors like different adhesion molecules such as the integrin family and CD44.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research