The Opportunistic Pathogen Corynebacterium bovis Augments Leukemia Patient Derived Xenograft Engraftment: A Cautionary Tale

Chronic Myelomonocytic Leukemia (CMML) is a lethal hematopoietic malignancy with no available cell line, primary culture cells, or murine models that fully recapitulate the disease. We have recently reported that the NSG-S mouse model, which expresses human interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and stem cell factor (SCF) uniquely support the hematopoietic engraftment of human Chronic Myelomonocytic Leukemia (CMML) resulting in a humanized model that fully recapitulates the human condition (REF).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research