Targeted Therapy in AML: Something for Everyone?
Are the myeloid malignancies leading the way, based on our ability to easily obtain tumor tissue and success in CML, or are they following, given the use of multi-gene panels to treat upfront advanced lung cancer and the remarkable outcomes using check point inhibitors to treat formerly intractable solid tumors? Past achievements in the leukemias have been impressive but incomplete. In chronic phase CML we have essentially curative treatments; in myeloproliferative neoplasms we know the mutations but possess only partially effective therapies; and in myelodysplastic syndrome many mutations have been described but effective therapies are lacking.
Publication date: August–September 2018Source: Medicina Intensiva (English Edition), Volume 42, Issue 6Author(s): F.D. Martos-Benítez, A. Gutiérrez-Noyola, M. Badal, N.A. DietrichAbstractObjectivesTo determine the risk factors for severe acute respiratory failure requiring invasive mechanical ventilation (SARF-MV) and its effect upon clinical outcomes in critically ill cancer patients.DesignA retrospective cohort study was carried out.SettingA 12-bed oncological intensive care unit (ICU) from January 2014 to December 2015.PatientsA total of 878 consecutive cancer patients were included. Patients with an...
Publication date: August–September 2018Source: Medicina Intensiva (English Edition), Volume 42, Issue 6Author(s): A. Carmona-Bayonas, F. Gordo, C. Beato, J. Castaño Pérez, P. Jiménez-Fonseca, J. Virizuela Echaburu, J. Garnacho-MonteroAbstractCancer patients are a vulnerable group exposed to numerous and serious risks beyond cancer itself. In recent years, the prognosis of these individuals has improved substantially thanks to several advances such as immunotherapy, targeted molecular therapies, surgical techniques, or developments in support treatment. This coincides with the prolonged survival o...
SKIN cancer symptoms are triggered when skin cells start to divide uncontrollably. There are two main types of skin cancer, called melanoma and non-melanoma skin cancer. Watch out for this major warning sign of skin cancer.
Emma Neagu, now 14, from Toronto, was diagnosed with a form of bone cancer known as osteosarcoma in 2016. The teen endured nine months of grueling chemotherapy.
This article focused on the CML and epigenetic and clinical significance. An electronic search of peer-reviewed articles was systematically performed to obtain the relevant literature with the CINAHL, cancer, Google scholar, self-experience and PubMed databases. The keywords included leukemia, cancer, illness, epigenetic. The inclusion criteria for the reviews were that the documents were original quantitative research and published in English. Articles that were not directly relevant to the present objective were excluded. Current progress in molecular biology and bioinformatics offer novel promising experiments namely as...
Authors: Steckiewicz KP, Barcińska E, Woźniak M Abstract Nerve growth factor (NGF) is protein discovered by Rita Levi Montalcini in the 1950s. It plays a crucial role in the development of nervous system. NGF may be produced by a variety of cells even beyond nervous system. NGF modulate cell metabolism by binding to p75NTR and TrkA receptors. NGF is involved in psychological processes and may be the possible therapeutical agent for diabetes, cancer and cardiovascular diseases, which will be described in the article. PMID: 30030957 [PubMed - in process]
BOWEL cancer symptoms occur when cells start to divide uncontrollably in the large intestine. Signs and symptoms can be observed in the toilet bowl, or through how someone is feeling. Watch out for these warning signs of colon cancer.
Obesity, Type 2 diabetes and metabolic syndrome, all of which have risen to epidemic levels in recent years, are linked to pancreatic cancer.
In July 2014, Phil Rech, then 59, was diagnosed with tonsil cancer.
Wenwen Zhang, Mengmeng Jiang, Jieying Chen, Rui Zhang, Yingnan Ye, Pengpeng Liu, Wenwen Yu, Jinpu Yu