Therapeutic TCR Mimic Monoclonal Antibodies to Intracellular Oncogenic Proteins

Nearly all tumor-specific targets and oncogenic proteins are intracellular proteins. Few are druggable with current small molecules. Neither mAb nor mAb-directed CAR T cells can enter the cell to recognize these proteins. In contrast, naturally occurring T cells are evolved to recognize MHC-presented peptide epitopes from intracellular proteins. These are generally derived from intracellular proteins. Therefore, there is a need to create antibodies that recognize antigens from intracellular, tumor specific and oncogenic proteins.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: David A. Scheinberg Source Type: research