Distinguishing CHIP from Myeloid Neoplasia

Peripheral blood develops from the hematopoietic stem cell (HSC), which is defined by its capacities for sustained self-renewal and multi-lineage differentiation. Normally, a diverse pool of HSCs is maintained in homeostatic balance and contributes to polyclonal hematopoiesis. Age-related development of clonally restricted hematopoiesis has been demonstrated by recent genetic studies in large populations of healthy individuals.1-3 During normal aging, individual HSCs steadily accumulate somatic mutations.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research