Leukemia Drug Bosutinib Shows Promise for Inherited Kidney Disease Leukemia Drug Bosutinib Shows Promise for Inherited Kidney Disease

The tyrosine kinase inhibitor bosutinib, approved for chronic myeloid leukemia, reduced kidney growth rate in patients with autosomal dominant polycystic kidney disease (ADPKD) in a phase 2 study.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Nephrology News Source Type: news

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Publication date: Available online 29 April 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Yaohua Cao, Ning Wan, Zhuoru Liang, Jingmei Xie, Sen Wang, Tengfei Lin, Tiantian Zhang, Jie JiangAbstractMany new regimens have been applied to newly diagnosed transplant-ineligible multiple myeloma, but no head-to-head research has been performed to compare the efficacy of these treatments. Currently lenalidomide plus dexamethasone (Rd) is one of the standard treatments. Our aim was to make a comparison of these treatments to Rd by a network meta-analysis. We performed a systematic review and network meta-analysis. We ...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: CellAuthor(s): Ninib Baryawno, Dariusz Przybylski, Monika S. Kowalczyk, Youmna Kfoury, Nicolas Severe, Karin Gustafsson, Konstantinos D. Kokkaliaris, Francois Mercier, Marcin Tabaka, Matan Hofree, Danielle Dionne, Ani Papazian, Dongjun Lee, Orr Ashenberg, Ayshwarya Subramanian, Eeshit Dhaval Vaishnav, Orit Rozenblatt-Rosen, Aviv Regev, David T. ScaddenSummaryStroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma have defined individual populations in th...
Source: Cell - Category: Cytology Source Type: research
ConclusionWe have designed several spiral microfluidic devices of various dimensions with enrichment and depletion outlets. We investigated the feasibility of using these devices to purify lymphocytes and more specifically T-cells from the leukocytes isolated from peripheral blood. We investigated the effect of channel dimensions, flow rate and microfluidic pressure on the separation of isolated leukocytes and determined the effect on cell viability and proliferation. The device was first optimized using a mixture of two cell lines differing in size; small Raji B lymphoblast-like cells and large A549 cells. We achieved 89 ...
Source: Cytotherapy - Category: Cytology Source Type: research
Conclusion MTDWe conducted a two-cohort, open-label study of the timing of toci on CTL019-associated CRS. Pts were 1-24 yo with CD19-expressing relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL). CTL019 was manufactured at the UPenn Cell and Vaccine Production Facility. Enrolled pts were assigned to high (≥ 40%) or low (38.5 C measured twice in 24 hours (“early toci”) and subsequently treated per standard CRS algorithm. Primary endpoint: frequency of gr4 CRS (Penn scale) in ≤5/15 pts. Secondary endpoints: D28 tumor response, remission duration, additional toxicities.RES78 pts were scre...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe established four distinct stable cell lines expressing firefly luciferase (fLuci) gene by infection of lentivirus in Jurkat, CCRF-CEM, Sup-T1 and CCRF-HSB2 ALL cells. 105 ALL/fLuci cells together with 106 MSCs were inoculated into NOD/SCID mice by intraperitoneal (IP) injection. And we measured luciferase activity using an IVIS optical imaging technique to determine the effects of MSCs on leukemic mass formation. Much higher luciferase activity was observed when ALL/fLuci cells were co-injected with MSCs as compared to that when ALL/fLuci cells were inoculated alone. In addition, we co-inoculated 105 ALL/fLuci...
Source: Cytotherapy - Category: Cytology Source Type: research
Authors: Valle-Jiménez X, Ramírez-Cosmes A, Aquino-Domínguez AS, Sánchez-Peña F, Bustos-Arriaga J, Romero-Tlalolini MLÁ, Torres-Aguilar H, Serafín-López J, Aguilar Ruíz SR Abstract Platelets are anucleate cells that have a role in several innate immune functions, including the secretion of proteins with antimicrobial activity. Several studies have demonstrated the ability of platelets to secrete thrombin-induced platelet microbicidal proteins and antimicrobial peptides, like hBD-1. However, the expression and secretion of defensins of the alpha family b...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Condition:   B-cell Acute Lymphoblastic Leukemia Interventions:   Drug: Inotuzumab ozogamicin;   Drug: Prednisone Pill;   Drug: Daunorubicin;   Drug: Vincristine;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Pegaspargase Sponsors:   University of Virginia;   Pfizer;   Vanderbilt University;   University of Wisconsin, Madison;   Virginia Commonwealth University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Irradiated Bone Marrow;   Transplant-Related Hematologic Malignancy;   Leukemia, Acute;   Multiple Myeloma;   Graft Vs Host Disease Interventions:   Drug: Conditioning treatment  " Treosulfan-TMI " ;   Procedure: SCT;   Drug: GvHD prophylaxis Sponsor:   IRCCS San Raffaele Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
MicroRNA-125a regulates proliferation and apoptosis of acute myeloid leukemia through targeting NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019 May;23(9):3594-3601 Authors: Shen MY, Wang Y, Cui SY, Wu XL, Guo Y, Xu RR Abstract OBJECTIVE: To elucidate the influence of microRNA-125a on the biological behaviors of acute myeloid leukemia (AML) cells. MATERIALS AND METHODS: MicroRNA-125a mimic and negative control (NC) were constructed and transfected into AML cell line HL60, respectively. Cell viability of HL60 cells transfected with microRNA-125a mimic or NC was determined by MTT (3-(4,5-dimethyl...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Sun W, Shen NM, Fu SL Abstract Cervical cancer (CC) develops, after human papillomavirus (HPV), an infection transmitted through sexual contact. Worldwide estimates are around>500,000 CC diagnoses and>300,000 related deaths annually, and CC remains the second most devastating type of cancers in women after breast cancer. Although the vaccine against HPV has reduced the incidence of infection and the treatment efficacy of the early-stage diagnoses has improved, many challenges remain in terms of treatment efficacy, during the late-stage and prevention of chemotherapy resistance development. Thus, new ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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