Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

Conclusion:Chymase might play an important role in vascular dysfunction via augmentation both of matrix metalloproteinase-9 activity and monocyte/macrophage accumulation in SHR-SP, and its inhibition may be useful for preventing vascular remodeling and prolonging survival.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Pathophysiological aspects Source Type: research