Radiation-Induced Liver Toxicity

The advent of highly conformal radiation therapy (RT) has defined a new role for RT in the treatment of both primary and metastatic liver cancer. Despite major advances in how RT is delivered, radiation-induced liver disease (RILD) remains a concern. Classic RILD, characterized by anicteric ascites and hepatomegaly, is unlikely to occur if treating to doses of ≤30Gy in 2Gy per fraction in patients with baseline Child-Pugh A liver function. On the other hand, nonclassic RILD is a spectrum of liver toxicity, including a general decline in liver function and elevation of liver enzymes.
Source: Seminars in Radiation Oncology - Category: Cancer & Oncology Authors: Source Type: research

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Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
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