Episode 7 of the Podcast ‘Countdown:’ The Strange Case of the Drowning Astronaut
There are a lot of things to like about walking in space—except for the fact that you can’t scratch your nose. A spacesuit, after all, is really more of a space vehicle, with its own sealed environmental system that must remain sealed if it’s going to keep you alive. You could no more open your helmet to relieve an itch or clear a fogged visor than you could open the window of your spacecraft itself. That’s generally a tolerable thing—until one day in July of 2013 when it became a terrifying thing. It was on that day that Italian astronaut Luca Parmitano stepped outside the International Space Station for what was supposed to be an uneventful six-hour spacewalk. He soon learned a deadly lesson: while a spacesuit is good at automatically purging any number of unwanted things, such as carbon dioxide and excess heat, it is terrible at dumping liquid water. Of course, spacesuits are not supposed to fill with water in the first place. But what if one did — what if the impossible thing did happen? The choice then would be between death by drowning in the fish bowl of your helmet or death by instant suffocation in the vacuum outside. Surviving to breathe Earthly air once again is not among the options. That, at least, is how it seemed to Parmitano on that summer day when his spacesuit went murderously awry. That’s how it seemed too to his fellow spacewalker Chris Cassidy, who watched in horror, helpless to assist him, and to the joint missi...
There are many ways to get rid of oily, greasy hair. These include changing how the hair is washed, the products used, and a number of natural remedies that could help. In this article, we look at 17 natural remedies that could improve the appearance of hair and make the scalp less itchy and uncomfortable.
HAY FEVER symptoms can be hard to contend with as you go about your day-to-day life. Sneezing, coughing and itchy eyes are just a few of the signs. Tablets and nasal sprays are recommended as treatment by the NHS, but introducing certain teas into your diet could also be the answer.
HAY FEVER symptoms can include sneezing, coughing, a runny nosy, itchy eyes, a headache and tiredness. They can have a big impact on how you go about your day-to-day life, and while the NHS recommends a number of treatments, such as tablets and nasal sprays, Dr Ranj Singh says applying a £1 skincare product to your nose can help.
Recent findings underscore an important role of IL-31/IL-31RA signalling in pruritus. In particular, the clinical efficacy of the IL-31RA-targeting antibody nemolizumab in treating itch in atopic dermatitis (AD) patients emphasized the importance of the IL-31/IL-31RA pathway. Although type 2 memory T cells are considered to be the major source of IL-31 production, the phenotype IL-31-producing T cells is poorly characterized. In the present study, we established a reliable protocol for intracellular IL-31 staining in restimulated T cells and investigated the detailed phenotype of IL-31-producing T cells in AD patients and healthy volunteers.
We report on wound healing and high correlation to patient reported outcomes in our Phase I/IIA clinical trial of ex vivo C7 gene therapy (LEAES grafts, EB-101) for treatment of chronic wounds in severe RDEB (N=7 adults, 36 wounds assessed). There is limited information on measuring dynamic wounds in RDEB and the amount of wound healing that is clinically meaningful in patient reported outcomes. We compared 2 methods to calculate wound surface area: quantitative 3D imaging with high-resolution Canfield camera (Vectra H1) vs.
Atopic dermatitis (AD) is a pruritic inflammatory dermatosis that causes significant psychosocial burden. While itch is most commonly implicated, pain is an under-recognized symptom. Eighty-one AD patients/caregivers from 10 countries (mean age: 34.5 years, range: 3 months to 74 years, 1 male: 2 female) completed a questionnaire regarding AD-related skin pain symptoms. Seventy-six percent suffer from skin pain along with itch. Pain is most common in the evening (70%) and overnight (48%), and can occur simultaneously with itch (61%), following itch (52%), or during scratching, even without an open wound present (55%).
While atopic dermatitis (AD) is known to impact sleep among clinical populations, little is known about the association between AD disease activity and sleep over time among community-based populations. We aimed to determine whether children with active AD have impaired sleep duration and quality compared to children without AD throughout childhood using data from 11,432 individuals in the Avon Longitudinal Study of Parents and Children, a population-based prospective birth cohort in the UK. The annual period prevalence of active AD (assessed by maternal report of a typical itchy flexural rash in the past year, as defined ...
The association of mood disorders such as depression and anxiety with chronic pruritus is established.Additionally, certain characteristics such as gender have been shown to increase the risk of concomitant mood disorder symptoms. However, the relationship between quality of life and mood disorder symptoms in patients with chronic pruritus is unknown. We performed a retrospective chart review of patients with chronic pruritus (defined as itch lasting>6 weeks)to assess both patient-reported mood disorder symptoms and quality of life using the Hospital Anxiety and Depression Scale and the Skindex-16, respectively.
Exposure to phenols and parabens (P&Ps) is an emerging concern and is purported to contribute to eczema. However, P&Ps ’ role in eczema and associated pruritus has not been studied. We investigated the association between P&Ps and pruritus and eczema using the 2005-2006 National Health&Nutrition Examination Survey Database to conduct a population-based cross-sectional analysis of 2202 participants. We evaluated the association between urine phenols (triclosan, bisphenol A, benzophenone-3, 4-tert-octylphenol) and parabens (butyl, ethyl, methyl, and propyl parabens) and itchy rash and eczema.
Plaque psoriasis (PsO) is a serious chronic immune dysregulation condition in which skin cells proliferate, build up, and form scales with itchy, dry raised patches. The cytokine IL-23, comprising the p19 and p40 subunits, has been implicated in the pathogenesis of psoriasis. Risankizumab, a humanized anti-IL-23 p19 antibody (single 18-mg dose at week 0, or 90- or 180-mg doses at weeks 0, 4, and 16), demonstrated superiority in the proportion of patients achieving 90% improvement from baseline in the Psoriasis Area and Severity Index (PASI 90) compared with ustekinumab, an anti-IL-12 p40 antibody (45 or 90 mg, according to...