Calmodulin inhibitor ameliorates cognitive dysfunction via inhibiting nitrosative stress and NLRP3 signaling in mice with bilateral carotid artery stenosis.

CONCLUSIONS: These data disclose novel findings about the therapeutic potential of DY-9836, and its encapsulated nanodrug delivery system significantly enhanced the cognitive function via inhibitory effect on nitrosative stress and NLRP3 signaling in VaD mice. PMID: 28851042 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28851042?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - August 28, 2017 Category: Neuroscience Authors: Wang R, Yin YX, Mahmood Q, Wang XJ, Gao YP, Gou GJ, Ahmed MM, Kohji F, Du YZ, Han F Tags: CNS Neurosci Ther Source Type: research