Family of bioactive heparins-coated iron oxide nanoparticles with positive contrast in magnetic resonance imaging for specific biomedical applications.

Family of bioactive heparins-coated iron oxide nanoparticles with positive contrast in magnetic resonance imaging for specific biomedical applications. Biomacromolecules. 2017 Aug 29;: Authors: Groult H, Poupard N, Herranz F, Conforto E, Bridiau N, Sannier F, Bordenave S, Piot JM, Ruiz-Cabello J, Fruitier-Arnaudin I, Maugard T Abstract Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWH) are well-known for their anticoagulant properties. There is also currently a growing interest in using LMWH in targeted cancer therapy. In particular, several types inhibit heparanase, a key enzyme overexpressed in the tumor microenvironment that promotes angiogenesis progression and metastasis spreading. Here, we propose iron oxide nanoparticles (HEP-IONP) coated with different heparins of distinct anticoagulant/anti-heparanase activity ratios and suitable for positive contrast in magnetic resonance imaging. As proof of concept, magnetic resonance angiography (MRA) were succeeded in mice up to 3 hours after intravenous administration. This new IONP-based positive contrast appropriate for clinic together with the long vascular circulating times can enabled innovative theranostic applications if combined with the various bioactivities of the heparins. Indeed, we showed using advanced in vitro tests, how HEP-IONP anticoagulant or anti-heparanase activities were maintained depending on the heparin species used for the coating. Overall, ...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research