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A caspase-independent way to kill cancer cells

Nature Cell Biology 19, 1014 (2017). doi:10.1038/ncb3604 Authors: Brent E. Fitzwalter &Andrew Thorburn Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research

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