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A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

Nature Cell Biology 19, 1012 (2017). doi:10.1038/ncb3602 Authors: Clea Bárcena &Carlos López-Otín Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research

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Publication date: August 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Volume 1863, Issue 8 Author(s): Daniel H. Lopez, Joan Bestard-Escalas, Jone Garate, Albert Maimó-Barceló, Roberto Fernández, Rebeca Reigada, Sam Khorrami, Daniel Ginard, Toshiro Okazaki, José A. Fernández, Gwendolyn Barceló-Coblijn Human colon lipid analysis by imaging mass spectrometry (IMS) demonstrates that the lipid fingerprint is highly sensitive to a cell's pathophysiological state. Along the colon crypt axis, and concomitant to the differentiation process, certai...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
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Source: Journal of Neurochemistry - Category: Neurology Source Type: research
Publication date: July 2018 Source:Stem Cell Research, Volume 30 Author(s): Ewelina Stelcer, Katarzyna Kulcenty, Marcin Rucinski, Karol Jopek, Magdalena Richter, Tomasz Trzeciak, Wiktoria Maria SuchorskaGraphical abstract
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 22 May 2018 Source:Stem Cell Research Author(s): Ryan P. Russell, Yu Fu, Yaling Liu, Peter Maye We have investigated the differentiation of paraxial mesoderm from mouse embryonic stem cells utilizing a Tbx6-EYFP/Brachyury (T)- Cherry dual reporter system. Differentiation from the mouse ESC state directly into mesoderm via Wnt pathway activation was low, but augmented by treatment with AGN193109, a pan-retinoic acid receptor inverse agonist. After five days of differentiation, T+ cells increased from 12.2% to 18.8%, Tbx6+ cells increased from 5.8% to 12.7%, and T+/Tbx6+ cells increased fr...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
DISCUSSION: We recommend audiological evaluation at initial FHL5 diagnosis to assess for hearing functions. Follow-up in audiology should be part of the long-term monitoring of patients with FHL5 as hearing loss could develop long after diagnosis. PMID: 29776323 [PubMed - in process]
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
Authors: Wang W, Xu Y, Jiang C, Gao Y Abstract Severe alcoholic hepatitis (SAH) is a costly and worldwide public health issue with high morbidity and mortality. Specific effective treatments for SAH have yet to be established. The aim of the present article is to review the current knowledge of the pathogenesis, assessment, and treatment options in patients with SAH. To date, alcohol abstinence and enteral nutrition are the recommended first-line treatments. Although corticosteroids remain the preferred therapy for certain patients with a modified Maddrey discriminant function level greater than 54, they only impro...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Several animal models have demonstrated improvement in mesenchymal stem cells (MSCs) count and paracrine secretions under hypoxic conditions. We have demonstrated an increase in adipose derived mesenchymal stem cells (ADMSCs) count in ischemic compared with nonischemic tissues in a previous in vivo study. This follow-up study was performed to investigate the effect of critical limb ischemia, in a human model, on in-situ ADMSCs paracrine effects.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Condition:   Myeloid Diseases Interventions:   Drug: Antithymocyte globulin (Rabbit);   Drug: fludarabine;   Radiation: total body irradiation;   Device: cyclophosphamide;   Drug: Rituxan;   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Li Q, Wu J, Chen S, Zhao Y Abstract The introduction of the theory of cancer stem cells (CSCs) has provided a new direction and perspective for our understanding of the nature and origin of tumors. Cancer stem cells are believed to be responsible for the treatment failure, drug tolerance, metastasis, and recurrence of tumors. However, it remains a challenge to identify or isolate tumor stem cells and determine their regulatory mechanisms. Therefore, further understanding of the biological characteristics and functions of CSCs is of great practical significance and value to develop new methods of tumor diag...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Abstract It takes several months to form the 3-dimensional morphology of the human embryonic brain. Therefore, establishing a long-term culture method for neuronal tissues derived from human induced pluripotent stem (iPS) cells is very important for studying human brain development. However, it is difficult to keep primary neurons alive for more than 3 weeks in culture. Moreover, long-term adherent culture to maintain the morphology of telencephalic neuron aggregates induced from human iPS cells is also difficult. Although collagen gel has been widely used to support long-term culture of cells, it is not clear whe...
Source: Cell Structure and Function - Category: Cytology Authors: Tags: Cell Struct Funct Source Type: research
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