Risk of atrial fibrillation in people with type 1 diabetes compared with matched controls from the general population: a prospective case-control study

Publication date: Available online 30 August 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Sofia Dahlqvist, Annika Rosengren, Soffia Gudbjörnsdottir, Aldina Pivodic, Hans Wedel, Mikhail Kosiborod, Ann-Marie Svensson, Marcus Lind Background Type 1 diabetes is associated with an increased risk of developing several cardiovascular complications. To our knowledge, the independent association between type 1 diabetes and atrial fibrillation has not been studied. Methods We did a prospective case-control study of individuals with type 1 diabetes in the Swedish National Diabetes Registry who were each matched with five controls for age, sex, and county of residence who were randomly selected from the Swedish Population Register. Cases of atrial fibrillation were obtained from the Swedish National Patient Registry. Findings We followed up 36 258 patients with type 1 diabetes and 179 980 controls between Jan 1, 2001, and Dec 31, 2013. Median follow-up was 9·7 years (IQR 5·2–13·0) for patients and 10·2 years (5·7–13·0) for controls. 749 (2%) individuals with type 1 diabetes and 2882 (2%) controls were diagnosed with atrial fibrillation, with an adjusted hazard ratio (HR) of 1·13 (95% CI 1·01–1·25; p=0·029) in men and 1·50 (1·30–1·72; p<0·0001) in women (p=0·0019 for interaction). The excess risk of atrial fibrillation in individuals with type 1 diabetes increased with worsening glycaemic control and renal complications....
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research