Noncoding RNAs, New Players in Pulmonary Medicine and Sarcoidosis.

Noncoding RNAs, New Players in Pulmonary Medicine and Sarcoidosis. Am J Respir Cell Mol Biol. 2017 Aug 29;: Authors: Salamo O, Mortaz E, Mirsaeidi M Abstract Noncoding RNAs (ncRNAs) are coded by 98% of the human genomic DNA. They are grouped into two major classes according to their length: small ncRNAs and long ncRNAs. They regulate genome organization and stability, and physiological processes that maintain cellular homeostasis. Recently, there has emerged a large interest in ncRNAs because of their significant roles in the development of several inflammatory diseases, including sarcoidosis. Some of them were introduced as novel markers for the disease activity, such increased levels of miRNA-34a that was found in peripheral blood mononuclear cells of sarcoidosis patients reemphasizing the inflammatory component in sarcoidosis. They are also important key factors in the outcome of sarcoidosis. Dysregulation of miRNA-let7f leads to overexpression of profibrotic factors and could be related to the pathogenesis of pulmonary fibrosis in patients with sarcoidosis due to the positive effect on collagen expression and deposition. However, many unanswered questions remain about the association of ncRNAs and sarcoidosis. By understanding the functions of ncRNAs in Th1 and Th-17 cells, we may be able to uncover the mechanism of action of those cells in sarcoidosis. The diagnostic potential in noncoding RNA is remarkable. Indeed, further tran...
Source: Am J Respir Cell Mol... - Category: Respiratory Medicine Authors: Tags: Am J Respir Cell Mol Biol Source Type: research