Alpha-1 microglobulin as a potential therapeutic candidate for the treatment of high blood pressure and oxidative stress in the STOX1 preeclampsia-model

Objectives: Preeclampsia (PE) is a serious pregnancy-related disease with hypertension and proteinuria manifesting after 20 weeks of gestation. The worldwide prevalence is 3-8%, making it the most common cause of maternal and fetal mortality. PE lacks an effective therapy, and the only “cure” is delivery. We have previously shown that exogenously administered alpha-1-microglobulin (A1M) alleviates PE-like symptoms and the effects of oxidative stress in a dual-placenta perfusion model as well as in pregnant animal PE-models.
Source: Placenta - Category: Reproduction Medicine Authors: Source Type: research