High fat diet linked to lower risk of death than diet high in carbs

Current global dietary guidelines need to change emphasis, say researchers Related items fromOnMedica High-quality carbs and unsaturated fats lower heart risks Low-carb diets appear to be safe for short-term use Fibre-rich diet linked to lowered risk of painful knee osteoarthritis Diet, lifestyle and cardiovascular disease Plant-based diet not always best for heart health
Source: OnMedica Latest News - Category: UK Health Source Type: news

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ConclusionDespite minimal group-level effects of chronic diet-induced obesity and voluntary wheel running on knee OA pathology under the current test durations, diet and exercise substantially altered the relationships among systemic and local variables associated with early-stage knee OA. These results suggest that distinct pre-OA phenotypes may exist prior to the development of disease.Graphical Abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
ConclusionAmong veterans undergoing primary THA at a VA hospital, patients undergoing DAA THA had better perioperative outcomes than patients treated with the posterior approach despite similar demographics, American Society of Anesthesiologists score, and the DAA learning curve.
Source: Journal of Arthroscopy and Joint Surgery - Category: Orthopaedics Source Type: research
The metabolic profile of cartilage is important to define as it relates to both normal and pathophysiological conditions. Our aim was to develop a precise, high-throughput method for gas/chromatography-mass/spectrometry (GC-MS) semi-targeted metabolic profiling of mouse cartilage.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Osteophyte formation is a critical part of the degeneration of a joint with osteoarthritis (OA). While often qualitatively described, few studies have succeeded in quantifying osteophyte growth over time. Using computed tomography (CT) image data from a longitudinal, observational study of thumb carpometacarpal (CMC) OA, our aim was to quantify osteophyte growth volume and location over a three-year period in men and women.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Conclusion10-week-old C57/BL6 male mice were induced to undergo OA by destabilization of medical meniscus (DMM) or SHAM surgery. 3 weeks post-surgery, mice were injected intra-articularly with saline or ferumoxytol-labeled murine MSCs (50 × 103 MSCs/mouse) to yield the following groups (n=5/group): i) DMM+MSC with ferumoxytol; ii) DMM+MSC without ferumoxytol iii) DMM+Saline; iv) SHAM+MSC; and v) SHAM+Saline. MRIs of mice were taken at 1, 3 days and 1, 2, or 4 weeks after injection. At 4 weeks post-injection, mice were scored for i) OARSI to determine cartilage damage and synovitis and ii) immunohistochemical chan...
Source: Cytotherapy - Category: Cytology Source Type: research
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1...
Source: Cytotherapy - Category: Cytology Source Type: research
Conclusion MethodThis is a single-arm, open-label, compassionate study at the Universiti Kebangsaan Malaysia Medical Centre (UKKMC) with 12 months follow-up period. Subjects with knee articular cartilage defect ICRS 3 diagnosed via diagnostic arthroscopy were treated with allogeneic UC-MSCs (Chondrocell-Ex, Cytopeutics, Malaysia) and assessed in five subsequent visits. During the visits, assessment was done following Visual Analog Score (VAS), International Knee Documentation Committee (IKDC), Tegner Activity Score (TAS), and Knee injury and Osteoarthritis Outcome Score (KOOS) scoring. At the end of the study, subjects und...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionHere we show that in twelve clinical cases, the cartilage was observed successfully regenerating and covering the defect region in knees after the intra-articular injection with adipose-derived mesenchymal stem cells (MSCs), and the treatment highly improves the symptoms of osteoarthritis. Basically, the adipose-derived MSCs from the patients are cultured and expanded to a specific amount with the optimized stem cell culture medium, the HELENE MEDIUM. After that, the cultured MSCs are directly injected into the injured knee joints of patients. The cartilage has gradually regenerated and been monitored by MRI phot...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionCulture of Wharton Jelly MSC at 1 litre with Solohill microcarriers showed 25% improved cell densities of the Bach impeller over the axial flow and paddle impellers: 4 × 10e5 cells/ml vs. 3 × 10e5 cells/ml. This was primarily due to extensive clumping of cell-microcarrier aggregates seen in the conventional impellers from day 3 onwards; whereas the laminar flow prevented aggregation up to the final day of harvesting.Significantly, when MSC were cultured on Cytodex microcarriers at 1 litre, cell yields increased dramatically to 15 × 10e5 cells/ml; viability and identity were equivalen...
Source: Cytotherapy - Category: Cytology Source Type: research
Conditions:   Knee Osteoarthritis;   Cartilage Injury Intervention:   Device: shock wave device Sponsor:   Peking University Third Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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